Metabolite exchange between stromal and tumor cells or among tumor cells themselves
accompanies metabolic reprogramming in cancer including pancreatic adenocarcinoma …

Metabolic compartmentalization of stroma-rich tumors, like pancreatic ductal
adenocarcinoma (PDAC), greatly contributes to malignancy. This involves cancer cells …

KRAS mutation, which occurs in∼ 95% of pancreatic ductal adenocarcinoma (PDA), has
been shown to program tumor metabolism. MCT4 is highly upregulated in a subset of PDA …

Objectives Novel treatments for pancreatic ductal adenocarcinoma (PDAC) are severely
needed. The aim of this work was to explore the roles of H+-lactate monocarboxylate …

The Warburg effect is known as the hyperactive glycolysis that provides the energy needed
for rapid growth and proliferation in most tumor cells even under the condition of sufficient …

Prostate cancer (PCa) is the most commonly diagnosed cancer in men worldwide.
Screening and management of PCa remain controversial and, therefore, the discovery of …

The monocarboxylate transporter (MCT) family member MCT1 can transport lactate into and
out of tumor cells. Whereas most oxidative cancer cells import lactate through MCT1 to fuel …

Objectives Because lactate is believed to support tumor growth, monocarboxylate
transporters (MCTs), which transport lactate, have been investigated in multiple tumors …

Background Cancer cell adopts peculiar metabolic strategies aimed to sustain the
continuous proliferation in an environment characterized by relevant fluctuations in oxygen …

Lactate, as the product of glycolytic metabolism and the substrate of energy metabolism, is
an intermediate link between cancer cell and tumor microenvironment metabolism. The …