Triacylglycerol (TAG) synthesis and storage in tissues such as adipose tissue and liver have
important roles in metabolic homeostasis. The molecular identification of genes encoding …

Triacylglycerols (TAG) serve as the predominant form of energy storage in mammalian cells,
and TAG synthesis influences conditions such as obesity, fatty liver, and insulin resistance …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of triacylglycerol. It has been well recognized that mammals possess multiple …

Glycerol-3-phosphate acyltransferases (GPATs; EC2. 3.1. 15) catalyze the first step in the de
novo synthesis of neutral lipids (triglycerides) and glycerophospholipids. The existence of …

Four homologous isoforms of glycerol-3-phosphate acyltransferase (GPAT), each the
product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3 …

Four glycerol-3-phosphate acyltransferase (GPAT) isoforms, each encoded by a separate
gene, catalyze the initial step in glycerolipid synthesis; in liver, the major isoforms are …

Microsomal and mitochondrial isoforms of glycerol-3-phosphate acyltransferase (GPAT; EC
2.3. 1.15) catalyze the committed step in glycerolipid synthesis. The mitochondrial isoform …

AGPAT6 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family
that appears to be important in triglyceride biosynthesis in several tissues, but the precise …

Abstract Glycerol-3-phosphate acyltransferase (GPAT) is the rate-limiting enzyme in the de
novo pathway of glycerolipid synthesis. It catalyzes the conversion of glycerol-3-phosphate …