[HTML][HTML] A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids
Abstract TWIK‐1, TREK‐1 and TASK K+ channels comprise a class of pore‐forming subunits
with four membrane‐spanning segments and two P domains. Here we report the cloning of …
with four membrane‐spanning segments and two P domains. Here we report the cloning of …
An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum
D Leonoudakis, AT Gray, BD Winegar… - Journal of …, 1998 - Soc Neuroscience
Tandem pore domain K+ channels represent a new family of ion channels involved in the
control of background membrane conductances. We report the structural and functional …
control of background membrane conductances. We report the structural and functional …
[HTML][HTML] TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family
H Bang, Y Kim, D Kim - Journal of Biological Chemistry, 2000 - ASBMB
Recently, several mammalian K+ channel subunits (TWIK, TREK-1, TRAAK, and TASK)
possessing four transmembrane segments and two pore-forming domains have been …
possessing four transmembrane segments and two pore-forming domains have been …
Thermosensitivity of the two‐pore domain K+ channels TREK‐2 and TRAAK
TREK‐1, TREK‐2 and TRAAK are members of the two‐pore domain K+ (K2P) channel
family and are activated by membrane stretch and free fatty acids. TREK‐1 has been shown …
family and are activated by membrane stretch and free fatty acids. TREK‐1 has been shown …
[HTML][HTML] TASK-3, a new member of the tandem pore K+ channel family
Y Kim, H Bang, D Kim - Journal of Biological Chemistry, 2000 - ASBMB
We have isolated from the rat cerebellum cDNA library a complementary DNA encoding a
new member of the tandem pore K+ channel family. Its amino acid sequence shares 54 …
new member of the tandem pore K+ channel family. Its amino acid sequence shares 54 …
Cloning and expression of human TRAAK, a polyunsaturated fatty acids‐activated and mechano‐sensitive K+ channel
F Lesage, F Maingret, M Lazdunski - FEBS letters, 2000 - Wiley Online Library
The two P domain hTRAAK K+ channel has been cloned from human brain. hTRAAK cDNA
encodes a 393 amino acid polypeptide with 88% of homology with its mouse counterpart …
encodes a 393 amino acid polypeptide with 88% of homology with its mouse counterpart …
Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels
J Levitz, P Royal, Y Comoglio… - Proceedings of the …, 2016 - National Acad Sciences
Twik-related K+ channel 1 (TREK1), TREK2, and Twik-related arachidonic-acid stimulated
K+ channel (TRAAK) form the TREK subfamily of two-pore-domain K+ (K2P) channels …
K+ channel (TRAAK) form the TREK subfamily of two-pore-domain K+ (K2P) channels …
[HTML][HTML] Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney
A complementary DNA encoding a novel K+ channel, called TASK-2, was isolated from
human kidney and its gene was mapped to chromosome 6p21. TASK-2 has a low sequence …
human kidney and its gene was mapped to chromosome 6p21. TASK-2 has a low sequence …
Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali
Y Kim, H Bang, C Gnatenco, D Kim - Pflügers Archiv, 2001 - Springer
TRAAK is a member of the tandem-pore K+ channel family, and is expressed mainly in the
brain. Using rat TRAAK (rTRAAK), we studied its single-channel kinetics, interactive modes …
brain. Using rat TRAAK (rTRAAK), we studied its single-channel kinetics, interactive modes …
The neuronal background K2P channels: focus on TREK1
E Honoré - Nature reviews neuroscience, 2007 - nature.com
Abstract Two-pore-domain K+ (K2P) channel subunits are made up of four transmembrane
segments and two pore-forming domains that are arranged in tandem and function as either …
segments and two pore-forming domains that are arranged in tandem and function as either …