Botulinum neurotoxins are the most toxic proteins currently known. Based on a recently
identified potent lead structure, 2, 4-dichlorocinnamic acid hydroxamate, herein we report on …

Botulinum neurotoxins (BoNTs) are the most toxic proteins known to man, exposure to which
results in flaccid paralysis. Given their extreme potency, these proteins have become studied …

Botulinum neurotoxins (BoNTs) are among the most deadly poisons known, though
ironically, they also are of great therapeutic utility. A number of research programs have …

Abstract Botulinum neurotoxin A (BoNT/A) is the most potent toxin known. Unfortunately, it is
also a potential bioweapon in terrorism, which is without an approved therapeutic treatment …

Botulinum neurotoxin serotype A (BoNT/A) is the most toxic protein known to man and also a
bioterrorism agent. As defined by our previous research targeting the etiological agent …

Botulinum neurotoxins (BoNTs), etiological agents of the deadly food poisoning disease
botulism, are the most toxic proteins currently known. Although only a few hundred cases of …

Botulinum neurotoxin (BoNT), the etiological agent that causes the neuroparalytic disease
botulism, has become a highly studied drug target in light of the potential abuse of this toxin …

Botulinum neurotoxins (BoNTs) are the most lethal biotoxins known to mankind and are
responsible for the neuroparalytic disease botulism. Current treatments for botulinum …

Botulinum Neurotoxins (BoNTs) are used therapeutically and in cosmetics, providing
potential for bioterrorist activity, thus driving the search for small-molecule BoNT inhibitors …

Botulinum neurotoxins (BoNTs) are the most lethal of biological substances, and are
categorized as class A biothreat agents by the Centers for Disease Control and Prevention …