Epigenetic regulatory proteins support mammalian development, cancer, aging and tissue
repair by controlling many cellular processes including stem cell self-renewal, lineage …

Polycomb group proteins are essential regulators of cell fate decisions during
embryogenesis. In mammals, at least five different Cbx proteins (Cbx2, Cbx4, Cbx6, Cbx7 …

Polycomb group proteins (PcG) form part of a gene regulatory mechanism that determines
cell fate during normal and pathogenic development. The mechanism relies on epigenetic …

Polycomb group (PcG) complexes are epigenetic regulatory complexes that conduct
transcriptional repression of target genes via modifying the chromatin. The two best …

The balance between self-renewal and differentiation of adult stem cells is essential for
tissue homeostasis. Here we show that in the haematopoietic system this process is …

Chromobox (CBX) family proteins control chromatin structure and gene expression.
However, the functions of CBXs in cancer progression, especially breast cancer, are …

The Polycomb group (PcG) proteins are essential for embryogenesis, and their expression is
often found deregulated in human cancer. The PcGs form two major protein complexes …

Abstract Polycomb repressive complex 1 (PRC1) is critical for mediating gene repression
during development and adult stem cell maintenance. Five CBX proteins, CBX2, 4, 6, 7, 8 …

Polycomb group proteins regulate self-renewal and differentiation in many stem cell
systems. When assembled into two canonical complexes, PRC1 and PRC2, they …

Summary The Polycomb Group (PcG) of chromatin modifiers regulates pluripotency and
differentiation. Mammalian genomes encode multiple homologs of the Polycomb repressive …