Nucleoside analogues such as acyclovir and ganciclovir have been the mainstay of therapy
for alphaherpesviruses (herpes simplex virus (HSV) and varicella-zoster virus (VZV)) and …

Antiviral drug resistance is an area of increasing clinical importance in treatment of a
number of viruses including herpes simplex virus (HSV) and human cytomegalovirus (CMV) …

During the past decade, potent agents against herpes simplex virus (HSV) types 1 and 2,
varicella-zoster virus (VZV), and cytomegalovirus (CMV) have become available. The …

The discovery of acyclovir (ACV), a nucleoside analogue, more than 30 years ago,
represents a milestone in the management of HSV and VZV infections. The modest activity …

In the past 4 years, interest in drug-resistant herpesviruses has evolved from the realm of
academic laboratory studies to that of great clinical importance. Recurrent and persistent …

Herpes simplex viruses (HSV) type 1 and type 2 are responsible for recurrent orolabial and
genital infections. The standard therapy for the management of HSV infections includes …

Herpes simplex virus (HSV) infections are efficiently treated with antiviral drugs such as
acyclovir (ACV). However, resistance has been reported, mainly among …

The study of resistance of herpesviruses to antiviral drugs provides an important tool for
understanding mechanisms of drug action and understanding clinical failures with antiviral …

Herpes simplex virus drug-resistance: new mutations and insi... : Current Opinion in Infectious
Diseases Herpes simplex virus drug-resistance: new mutations and insights : Current Opinion …

In herpes simplex virus, the simplest path to resistance to the drug acyclovir is a mutation
that knocks out the enzyme thymidinc kinasc. Such mutants arc highly attenuated in mouse …