[HTML][HTML] Inhibition of spores to prevent the recurrence of Clostridioides difficile infection-A possibility or an improbability?

CW Chiu, PJ Tsai, CC Lee, WC Ko, YP Hung - Journal of Microbiology …, 2021 - Elsevier
Clostridioides difficile is one of the most common nosocomial gastrointestinal pathogens,
and recurrence is a problematic issue because approximately 20–30% of patients …

Treatment issues in recurrent Clostridioides difficile infections and the possible role of germinants

N Budi, N Safdar, WE Rose - FEMS microbes, 2020 - academic.oup.com
Clostridioides difficile is the number one cause of hospital-acquired infections in the United
States and one of the CDC's urgent-level pathogen threats. The inflammation caused by …

[HTML][HTML] Frontiers in antibiotic alternatives for Clostridioides difficile infection

M Phanchana, P Harnvoravongchai… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Clostridioides difficile (C. difficile) is a gram-positive, anaerobic spore-forming bacterium and
a major cause of antibiotic-associated diarrhea. Humans are naturally resistant to C. difficile …

Emerging alternatives against Clostridioides difficile infection

A Romero-Rodríguez, CM de la Peña… - Anaerobe, 2022 - Elsevier
Clostridioides difficile infection (CDI) is a significant worry within healthcare institutions and
the community. It is one of the leading agents causing severe diarrhea worldwide. Effective …

Clostridioides difficile Spore Formation and Germination: New Insights and Opportunities for Intervention

A Shen - Annual review of microbiology, 2020 - annualreviews.org
Spore formation and germination are essential for the bacterial pathogen Clostridioides
difficile to transmit infection. Despite the importance of these developmental processes to the …

[HTML][HTML] Clostridioides difficile infection: are the three currently used antibiotic treatment options equal from pharmacological and microbiological points of view?

M Krutova, M Wilcox, E Kuijper - International Journal of Infectious Diseases, 2022 - Elsevier
Recently, the recommendations for the treatment of Clostridioides difficile infection (CDI)
have been updated. However, in addition to the clinical efficacy data, the drug of choice …

[HTML][HTML] Advances in Therapeutic Strategies for the Management of Clostridioides difficile Infection

A Vitiello, M Sabbatucci, A Zovi, A Salzano… - Journal of Clinical …, 2024 - mdpi.com
The infection caused by Clostridioides difficile represents one of the bacterial infections with
the greatest increase in incidence among nosocomial infections in recent years. C. difficile is …

Therapeutics for Clostridioides difficile infection: molecules and microbes

S Khanna, E Voth - Expert Review of Gastroenterology & …, 2023 - Taylor & Francis
Introduction Clostridioides difficile infection (CDI) is a major healthcare problem in the
developed world, and effective management of recurrent infection remains one of the …

Current and Ongoing Developments in Targeting Clostridioides difficile Infection and Recurrence

WY Cun, PA Keller, SG Pyne - Microorganisms, 2024 - mdpi.com
Clostridioides difficile is a Gram-positive, spore-forming anaerobic bacterial pathogen that
causes severe gastrointestinal infection in humans. This review provides background …

Tackling the recurrence of Clostridium difficile infection

N Petrosillo - Médecine Et Maladies Infectieuses, 2018 - Elsevier
The pathogenesis of recurrent Clostridium difficile infection (CDI) is still poorly understood.
The risk of recurrence is approximately 20% after an initial CDI episode and dramatically …