Myelin membranes are dominated by lipids while the complexity of their protein composition
has long been considered to be low. However, numerous additional myelin proteins have …

Proteome and transcriptome analyses aim at comprehending the molecular profiles of the
brain, its cell-types and subcellular compartments including myelin. Despite the relevance of …

Human myelin disorders are commonly studied in mouse models. Since both clades
evolutionarily diverged approximately 85 million years ago, it is critical to know to what …

Molecular characterization of myelin is a prerequisite for understanding the normal structure
of the axon/myelin-unit in the healthy nervous system and abnormalities in myelin-related …

Rapid nerve conduction in the CNS is facilitated by insulation of axons with myelin, a
specialized oligodendroglial compartment distant from the cell body. Myelin is turned over …

Myelin, formed by oligodendrocytes (OLs) in the CNS, is critical for axonal functions, and its
damage leads to debilitating neurological disorders such as multiple sclerosis …

Myelin formation and maintenance depends on the establishment of two structurally and
biochemically discernible domains:(a) compact myelin, that is multilamellar stacks of plasma …

Fast-transmitting vertebrate axons are electrically insulated with multiple layers of
nonconductive plasma membrane of glial cell origin, termed myelin. The myelin membrane …

Rapid signal propagation along vertebrate axons is facilitated by their insulation with myelin,
a plasma membrane specialization of glial cells. The recent application of 'omics' …

To understand the molecular anatomy of myelin membranes, we performed a large‐scale,
liquid chromatography‐coupled tandem mass spectrometry (LC‐MS/MS)‐based lipidome …