The present study aimed to explore the renoprotective effect of metformin on diabetic
nephropathy in type 2 diabetic rats. A rat model of type 2 diabetic nephropathy (T2DN) was …

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting
from defects in insulin secretion and/or action. One of the most important complications of …

Metformin, a biguanide drug, is widely prescribed to treat high blood glucose in individuals
with type 2 diabetes mellitus. Type 2 diabetes mellitus is a troubling chronic disease and …

Diabetic nephropathy (DN) is the major microvascular complication of diabetes mellitus and
the most important cause of end‐stage renal disease worldwide. Metformin is the preferred …

AIMS: Diabetic nephropathy (DN) is an important microvascular complication and one of the
main causes of end-stage renal disease. In this study, the preventive effect and mechanism …

Diabetic nephropathy (DN) is the major cause of end-stage renal disease. The early
changes in DN are characterized by an increased in kidney size, glomerular volume, and …

Diabetic nephropathy (DN) has high prevalence and poor prognosis which make it a
research priority for scientists. Since metformin, a hypoglycaemic drug, has been found to …

Background: Diabetic nephropathy is one of the most important complications in patients
with diabetes mellitus. Main steps crucial for the pathogenesis of diabetic nephropathy …

Hyperglycemia promotes oxidative stress and hence generation of reactive oxygen species
(ROS), which is known to play a crucial role in the pathogenesis of diabetic nephropathy …

Metformin, a well‐known anti‐diabetic agent, is very effective in lowering blood glucose in
patients with type 2 diabetes with minimal side‐effects. Metformin is also being …