Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in …
J Quddus, KJ Johnson, J Gavalchin… - The Journal of …, 1993 - Am Soc Clin Investig
Human antigen-specific CD4+ T cells become autoreactive after treatment with various DNA
methylation inhibitors, including 5-azacytidine, procainamide, and hydralazine. This …
methylation inhibitors, including 5-azacytidine, procainamide, and hydralazine. This …
Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.
E Cornacchia, J Golbus, J Maybaum… - … (Baltimore, Md.: 1950 …, 1988 - journals.aai.org
Inhibitors of DNA methylation, such as 5-azacytidine, induce gene expression. We have
previously reported that cloned T cells treated with 5-azacytidine lose the requirement for Ag …
previously reported that cloned T cells treated with 5-azacytidine lose the requirement for Ag …
Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.
RL Yung, J Quddus, CE Chrisp, KJ Johnson… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
Treating activated CD4+ T cells with DNA methyltransferase inhibitors modifies gene
expression and induces autoreactivity. Adoptive transfer of viable polyclonal autoreactive …
expression and induces autoreactivity. Adoptive transfer of viable polyclonal autoreactive …
Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
B Richardson, L Scheinbart, J Strahler… - … : Official Journal of …, 1990 - Wiley Online Library
Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in
cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a …
cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a …
Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in …
R Yung, D Powers, K Johnson… - The Journal of …, 1996 - Am Soc Clin Investig
Current theories propose that systemic lupus erythematosus develops when genetically
predisposed individuals are exposed to certain environmental agents, although how these …
predisposed individuals are exposed to certain environmental agents, although how these …
Phenotypic and functional similarities between 5‐azacytidine‐treated t cells and at cell subset in patients with active systemic lupus erythematosus
BC Richardson, JR Strahler, TS Pivirotto… - … : Official Journal of …, 1992 - Wiley Online Library
Abstract Objective. Antigen‐specific CD4+ T cells treated with DNA methylation inhibitors
become autoreactive, suggesting a novel mechanism for autoimmunity. To test whether this …
become autoreactive, suggesting a novel mechanism for autoimmunity. To test whether this …
Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells
B Richardson - Human immunology, 1986 - Elsevier
During T-cell maturation, thymocytes interact with thymic stromal major histocompatibility
complex (MHC) determinants and thymic hormones, and proliferate, apparently in response …
complex (MHC) determinants and thymic hormones, and proliferate, apparently in response …
Mechanisms of drug‐induced lupus. IV. Comparison of procainamide and hydralazine with analogs in vitro and in vivo
R Yung, S Chang, N Hemati, K Johnson… - … : Official Journal of …, 1997 - Wiley Online Library
Objective. T cells treated with DNA methylation inhibitors overexpress lymphocyte function‐
associated antigen 1 (LFA‐1), which results in autoreactivity, and the autoreactive cells …
associated antigen 1 (LFA‐1), which results in autoreactivity, and the autoreactive cells …
Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs
Q Lu, A Wu, BC Richardson - The Journal of Immunology, 2005 - journals.aai.org
Exposing genetically predisposed individuals to certain environmental agents is believed to
cause human lupus. How environmental agents interact with the host to cause lupus is …
cause human lupus. How environmental agents interact with the host to cause lupus is …
Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus.
A Kretz-Rommel, SR Duncan… - The Journal of clinical …, 1997 - Am Soc Clin Investig
A side effect of therapy with procainamide and numerous other medications is a lupus-like
syndrome characterized by autoantibodies directed against denatured DNA and the (H2A …
syndrome characterized by autoantibodies directed against denatured DNA and the (H2A …