CDKL5 Deficiency Disorder (CDD) is a rare, X-linked dominant condition that causes a
developmental and epileptic encephalopathy (DEE). The incidence is between~ 1: 40,000 …

Background Pathologic mutations in cyclin-dependent kinase-like 5 cause CDKL5
deficiency disorder, a genetic syndrome associated with severe epilepsy and cognitive …

Background CDKL5 deficiency disorder (CDD) is associated with refractory infantile onset
epilepsy, global developmental delay, and variable features that include sleep, behavioral …

Abstract Background CDKL5 Deficiency Disorder (CDD) is a rare genetic disorder caused
by a mutation in the cyclin-dependent kinase-like 5 (CDKL5) gene. It is now considered to …

CDKL5 deficiency disorder (CDD) results in early-onset seizures and severe developmental
impairments. A CDD clinical severity assessment (CCSA) was previously developed with …

CDKL5 deficiency disorder (CDD) is a complex of clinical symptoms resulting from the
presence of non-functional CDKL5 protein, ie, serine-threonine kinase (previously referred …

Abstract Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a
developmental and epileptic encephalopathy with infantile-onset epilepsy. Most individuals …

Abstract Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a
developmental encephalopathy caused by pathogenic variants in the gene CDKL5. This …

Objective The cyclin‐dependent kinase like 5 (CDKL5) gene is a known cause of early onset
developmental and epileptic encephalopathy, also known as CDKL5 deficiency disorder …

CDKL5 deficiency disorder (CDD) is an X-linked brain disorder of young children and is
caused by pathogenic variants in the cyclin-dependent kinase-like 5 (CDKL5) gene …