Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy
haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic …

Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …

Cell cycle quiescence is a critical feature contributing to haematopoietic stem cell (HSC)
maintenance. Although various candidate stromal cells have been identified as potential …

Continuous supply of immune cells throughout life relies on the delicate balance in the
hematopoietic stem cell (HSC) pool between long-term maintenance and meeting the …

Haematopoietic stem cells (HSCs) reside in specialized microenvironments in the bone
marrow—often referred to as 'niches'—that represent complex regulatory milieux influenced …

Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during
aging but are functionally impaired. However, the role of HSC-intrinsic and-extrinsic aging …

Haematopoietic stem and progenitor cells (HSPCs) change location during development
and circulate in mammals throughout life, moving into and out of the bloodstream to engage …

Quiescent hematopoietic stem cells (HSCs) are typically dormant, and only a few quiescent
HSCs are active. The relationship between" dormant" and" active" HSCs remains …

Bone marrow hematopoietic stem cells (HSCs) are crucial to maintain lifelong production of
all blood cells. Although HSCs divide infrequently, it is thought that the entire HSC pool turns …

Aging of hematopoietic stem cells (HSCs) is associated with a decline in their regenerative
capacity and multilineage differentiation potential, contributing to the development of blood …