The mammalian CNS is capable of tolerating chronic hypoxia, but cell type-specific
responses to this stress have not been systematically characterized. In the Norrin KO (Ndp …

Norrin is a secreted protein that is involved in retinal angiogenesis and activates the Wnt-
signaling pathway. We studied the role of Norrin in microvascular endothelial cells in vitro …

Abstract Treatment of a mouse model of oxygen-induced retinopathy (OIR) with recombinant
human Norrin (Norrie Disease Protein, gene: NDP) accelerates regrowth of the …

Purpose.: To define the role of hypoxia and vascular endothelial growth factor (VEGF) in
modifying the pattern, density, and permeability of the retinal vasculature in mouse models …

Oxygen delivery to the retinal pigment epithelium and the outer retina is essential for
metabolism, function, and survival of photoreceptors. Chronically reduced oxygen supply …

purpose. To examine the response of mouse retina to sustained hyperoxia. Hyperoxia is
toxic to photoreceptors after sustained exposure (7–14 days in the C57BL/6J mouse) but …

purpose. This study was conducted to evaluate whether regions of the retinal neuropile
become hypoxic during periods of high oxygen consumption and whether depletion of the …

Purpose.: Wnt-signaling has been implicated in retinal development. The aim of this study
was to investigate the possibility of improving retinal vasculature in an animal model of …

purpose. To characterize developmental defects and the time course of Norrie disease in
retinal and hyaloid vasculature during retinal development and to identify underlying …

Purpose A gene expression analysis of hypoxic rat retina was undertaken to gain a deeper
understanding of the possible molecular mechanisms that underlie hypoxia-induced retinal …