Ketamine ameliorates depressive-like behaviors in mice through increasing glucose uptake regulated by the ERK/GLUT3 signaling pathway
X Ouyang, Z Wang, M Luo, M Wang, X Liu, J Chen… - Scientific Reports, 2021 - nature.com
To investigate the effects of ketamine on glucose uptake and glucose transporter (GLUT)
expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7 …
expression in depressive-like mice. After HA1800 cells were treated with ketamine, 2-[N-(7 …
Downregulation of Egr-1 expression level via GluN2B underlies the antidepressant effects of ketamine in a chronic unpredictable stress animal model of depression
W Zhang, H Wang, Y Lv, C Liu, W Sun, L Tian - Neuroscience, 2018 - Elsevier
Ketamine is a non-competitive antagonist of N-methyl-D-aspartate receptors (NMDARs).
Growing evidence suggests that a single dose of ketamine produces a series of rapid and …
Growing evidence suggests that a single dose of ketamine produces a series of rapid and …
Ketamine alleviates depressive-like behaviors via down-regulating inflammatory cytokines induced by chronic restraint stress in mice
S Tan, Y Wang, K Chen, Z Long, J Zou - … and Pharmaceutical Bulletin, 2017 - jstage.jst.go.jp
The purpose of the present study was to investigate whether ketamine's rapid
antidepressant effects were associated with its anti-inflammatory actions and to explore the …
antidepressant effects were associated with its anti-inflammatory actions and to explore the …
S-ketamine exerts antidepressant effects by regulating Rac1 GTPase mediated synaptic plasticity in the hippocampus of stressed rats
X Zhu, F Zhang, Y You, H Wang, S Yuan, B Wu… - Cellular and Molecular …, 2023 - Springer
Clinical studies have found that ketamine has a rapid and lasting antidepressant effect,
especially in the case of patients with major depressive disorder (MDD). The molecular …
especially in the case of patients with major depressive disorder (MDD). The molecular …
Rosiglitazone mitigates dexamethasone-induced depression in mice via modulating brain glucose metabolism and AMPK/mTOR signaling pathway
Major depressive disorder (MDD) is a common, complex disease with poorly understood
pathogenesis. Disruption of glucose metabolism is implicated in the pathogenesis of …
pathogenesis. Disruption of glucose metabolism is implicated in the pathogenesis of …
Ketamine triggers rapid antidepressant effects by modulating synaptic plasticity in a new depressive-like mouse model based on astrocyte glutamate transporter GLT …
MN Fullana, V Paz, F Artigas, A Bortolozzi - Revista de Psiquiatría y Salud …, 2022 - Elsevier
Objective Recently, we reported on a new MDD-like mouse model based on a regionally
selective knockdown of astroglial glutamate transporters, GLAST/GLT-1, in infralimbic cortex …
selective knockdown of astroglial glutamate transporters, GLAST/GLT-1, in infralimbic cortex …
A single dose of ketamine cannot prevent protracted stress-induced anhedonia and neuroinflammation in rats
R Moraga-Amaro, CGJ Guerrin, L Reali Nazario… - Stress, 2022 - Taylor & Francis
Worldwide, millions of people suffer from treatment-resistant depression. Ketamine, a
glutamatergic receptor antagonist, can have a rapid antidepressant effect even in treatment …
glutamatergic receptor antagonist, can have a rapid antidepressant effect even in treatment …
Low-dose ketamine improves LPS-induced depression-like behavior in rats by activating cholinergic anti-inflammatory pathways
J Zhao, X Liu, D Chang, X Zhang, H Lian… - ACS Chemical …, 2020 - ACS Publications
About 16% of the world's population has major depressive disorder. Traditional
antidepressants have slow effect rates and low response rates. Many studies have shown …
antidepressants have slow effect rates and low response rates. Many studies have shown …
Regulation of glutamate transporter 1 via BDNF-TrkB signaling plays a role in the anti-apoptotic and antidepressant effects of ketamine in chronic unpredictable stress …
WX Liu, J Wang, ZM Xie, N Xu, GF Zhang, M Jia… - …, 2016 - Springer
Rationale Growing evidence suggests that downregulated clearance of glutamate and
signaling pathways involving brain-derived neurotrophic factor (BDNF) and its receptor TrkB …
signaling pathways involving brain-derived neurotrophic factor (BDNF) and its receptor TrkB …
Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model
HL Sun, ZQ Zhou, GF Zhang, C Yang, XM Wang… - Translational …, 2016 - nature.com
Although ketamine shows a rapid and sustained antidepressant effect, the precise
mechanisms underlying its effect are unknown. Recent studies indicate a key role of p11 …
mechanisms underlying its effect are unknown. Recent studies indicate a key role of p11 …