1. The yield of mitochondria isolated from perfused hearts subjected to 30 min ischaemia
followed by 15 min reperfusion was significantly less than that for control hearts, and this …

Mammalian cardiomyocytes may withstand prolonged periods of ischaemia, only to die on
reperfusion. We review data that implicate mitochondrial dysfunction as a basis for …

The permeability properties of a putative Ca2 (+)-activated pore in heart mitochondria, of
possible relevance to re-perfusion-induced injury, have been investigated by a pulsed-flow …

Reperfusion following a period of ischemia can salvage the myocardium only if the ischemic
episode has not exceeded a certain time limit; beyond this point damage becomes …

Previous in vitro studies have shown that isolated mitochondria can generate oxygen
radicals. However, whether a similar phenomenon can also occur in intact organs is …

Two mitochondrial subpopulations were isolated from guinea-pig heart by density gradient
centrifugation. Under control conditions, both contain functionally intact mitochondria in …

Evidence that the Ca2+‐induced permeabilization of mitochondria is attributable to a
reversible Ca2+‐activated pore [Al Nasser & Crompton (1986) Biochem. J. 239, 19–29] has …

The mitochondrial permeability transition (mPT) involves the opening of a non-specific pore
in the inner membrane of mitochondria, converting them from organelles whose production …

The effect of inhibition of the mitochondrial ATPase with oligomycin on the rate of ATP
depletion and anaerobic glycolysis was studied in the totally ischemic dog heart. An …

In the present study, isolated dog and rat hearts were perfused in the Langendorff mode with
Krebs bicarbonate buffer in the absence and presence of 10 (-5) M oligomycin. The …