Treatment effects of interleukin-6 receptor antibodies for modulating the systemic inflammatory response after out-of-hospital cardiac arrest (The IMICA Trial) a double …

MAS Meyer, S Wiberg, J Grand, ASP Meyer… - Circulation, 2021 - Am Heart Assoc
Background: Patients experiencing out-of-hospital cardiac arrest who remain comatose after
initial resuscitation are at high risk of morbidity and mortality attributable to the ensuing post …

Inflammatory markers following resuscitation from out-of-hospital cardiac arrest—a prospective multicenter observational study

MA Peberdy, LW Andersen, A Abbate, LR Thacker… - Resuscitation, 2016 - Elsevier
Aim The post-cardiac arrest syndrome is a complex set of pathophysiological processes
including a systemic inflammatory response. The goal of the current investigation was to test …

Randomized trial of interleukin-6 receptor inhibition in patients with acute ST-segment elevation myocardial infarction

K Broch, AK Anstensrud, S Woxholt, K Sharma… - Journal of the American …, 2021 - jacc.org
Background Prompt myocardial revascularization with percutaneous coronary intervention
(PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation …

Successful cardiopulmonary resuscitation after cardiac arrest as a “sepsis-like” syndrome

C Adrie, M Adib-Conquy, I Laurent, M Monchi… - Circulation, 2002 - Am Heart Assoc
Background—We investigated the immunoinflammatory profile of patients successfully
resuscitated after cardiac arrest, representing a model of whole-body ischemia/reperfusion …

Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction

O Kleveland, T Ueland, G Kunszt, M Bratlie… - International Journal of …, 2018 - Elsevier
Aim To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network
in patients with acute non-ST-elevation myocardial infarction (NSTEMI). Methods 117 …

[HTML][HTML] The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study

H Langeland, JK Damås, TE Mollnes, JK Ludviksen… - Resuscitation, 2022 - Elsevier
Background Whole body ischemia and reperfusion injury after cardiac arrest leads to the
massive inflammation clinically manifested in the post-cardiac arrest syndrome. Previous …

The role of inflammatory cytokines in cardiac arrest

C Jou, R Shah, A Figueroa… - Journal of intensive care …, 2020 - journals.sagepub.com
Introduction: Post-cardiac arrest syndrome (PCAS) is characterized by systemic
ischemia/reperfusion injury, anoxic brain injury, and post-arrest myocardial dysfunction …

Predictive value of interleukin-6 in post-cardiac arrest patients treated with targeted temperature management at 33 C or 36 C

J Bro-Jeppesen, J Kjaergaard, P Stammet, MP Wise… - Resuscitation, 2016 - Elsevier
Aim Post-cardiac arrest syndrome (PCAS) is characterized by systemic inflammation,
however data on the prognostic value of inflammatory markers is sparse. We sought to …

Level of systemic inflammation and endothelial injury is associated with cardiovascular dysfunction and vasopressor support in post-cardiac arrest patients

J Bro-Jeppesen, PI Johansson, J Kjaergaard… - Resuscitation, 2017 - Elsevier
Aim Post-cardiac arrest syndrome (PCAS) is characterized by a sepsis-like inflammatory
response and hemodynamic instability. We investigated the associations between systemic …

The immunology of the post-cardiac arrest syndrome

CA Cunningham, PJ Coppler, AB Skolnik - Resuscitation, 2022 - Elsevier
Patients successfully resuscitated from cardiac arrest often have brain injury, myocardial
dysfunction, and systemic ischemia–reperfusion injury, collectively termed the post-cardiac …