The blood–brain barrier (BBB) limits the access of substances to the central nervous system
(CNS) which hinders the treatment of pathologies affecting the brain and the spinal cord …

This review aims to summarize the non-invasive approaches employed in delivering drugs
to the central nervous system which is severely hindered by the presence of the blood-brain …

Publisher Summary The development of techniques aimed at the successful delivery of
drugs to the CNS has most recently focused directly on the problem of penetrating the blood …

The central nervous system (CNS) is protected by various barriers, which regulate nervous
tissue homeostasis and control the selective and specific uptake, efflux, and metabolism of …

Background: The blood brain barrier (BBB) is a dynamic and functional structure which
poses a vast challenge in the development of drugs acting on the central nervous system …

The possibility to treat central nervous system (CNS) disorders is strongly limited by the poor
access of many therapeutic agent to the target tissues. This is mainly due to the presence of …

Context: Delivery of a drug into the central nervous system (CNS) is considered difficult.
Most of the drugs discovered over the past decade are biological, which are high in …

Although many agents have therapeutic potentials for central nervous system (CNS)
diseases, few of these agents have been clinically used because of the brain barriers. As the …

The presence of a blood-brain barrier (BBB) and a blood-cerebrospinal fluid barrier presents
a huge challenge for effective delivery of therapeutics to the central nervous system (CNS) …

The Neurodegenerative diseases, cancer and infections of the brain are becoming more
prevalent in society as population become older. Nowadays, these diseases represent a …