New perspectives of physiological and pathological functions of nucleolin (NCL)

W Jia, Z Yao, J Zhao, Q Guan, L Gao - Life sciences, 2017 - Elsevier
Nucleolin (NCL) is a multifunctional protein that mainly localized in the nucleolus, it is also
found in the nucleoplasm, cytoplasm and cell membrane. The three main structural domains …

The roles of nucleolin subcellular localization in cancer

CM Berger, X Gaume, P Bouvet - Biochimie, 2015 - Elsevier
Nucleolin (NCL) is one of the most abundant non ribosomal protein of the nucleolus where it
plays a central role in polymerase I transcription. NCL is also found outside of the nucleolus …

Multifaceted nucleolin protein and its molecular partners in oncogenesis

I Ugrinova, M Petrova, M Chalabi-Dchar… - Advances in protein …, 2018 - Elsevier
Discovered in 1973, nucleolin is one of the most abundant phosphoproteins of the
nucleolus. The ability of nucleolin to be involved in many cellular processes is probably …

[HTML][HTML] Roles of nucleolin: Focus on cancer and anti-cancer therapy

Z Chen, XH Xu - Saudi medical journal, 2016 - ncbi.nlm.nih.gov
Nucleolin, a multifunctional protein distributed in the nucleolus, participates in many
modulations including rDNA transcription, RNA metabolism, and ribosome assembly …

Molecular dissection of nucleolin's role in growth and cell proliferation: new insights

M Srivastava, HB Pollard - The FASEB Journal, 1999 - Wiley Online Library
Cells require optimum protein synthetic activity in order to support cell proliferation, maintain
homeostatic and metabolic integrity, and repair damage. Since growth depends on protein …

RNA-binding protein nucleolin in disease

K Abdelmohsen, M Gorospe - RNA biology, 2012 - Taylor & Francis
Nucleolin is a multifunctional protein localized primarily in the nucleolus, but also found in
the nucleoplasm, cytoplasm and cell membrane. It is involved in several aspects of DNA …

Nucleolin: dual roles in rDNA chromatin transcription

N Durut, J Sáez-Vásquez - Gene, 2015 - Elsevier
Nucleolin is a major nucleolar protein conserved in all eukaryotic organisms. It is a
multifunctional protein involved in different cellular aspects like chromatin organization and …

Nucleolin: The most abundant multifunctional phosphoprotein of nucleolus

MM Tajrishi, R Tuteja, N Tuteja - Communicative & integrative …, 2011 - Taylor & Francis
Nucleolin is multifunctional phosphoprotein ubiquitously distributed in the nucleolus,
nucleus and cytoplasm of the cell. Nucleolin has a bipartite nuclear localization signal …

Cell surface nucleolin as a target for anti-cancer therapies

M Koutsioumpa, E Papadimitriou - Recent patents on anti …, 2014 - ingentaconnect.com
A large number of mostly recent reports show enhanced expression of the multi-functional
protein nucleolin (NCL) on the surface of activated lymphocytes, angiogenic endothelial and …

Nucleolin: a multiFACeTed protein

F Mongelard, P Bouvet - Trends in cell biology, 2007 - cell.com
Nucleolin is an abundant, ubiquitously expressed protein that is found in various cell
compartments, especially in the nucleolus, of which it is a major component. This …