AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes
A Garabedian, K Jeanne Dit Fouque… - Nucleic Acids …, 2022 - academic.oup.com
The mammalian high mobility group protein AT-hook 2 (HMGA2) houses three motifs that
preferentially bind short stretches of AT-rich DNA regions. These DNA binding motifs, known …
preferentially bind short stretches of AT-rich DNA regions. These DNA binding motifs, known …
Exploring the Conformational and Binding Dynamics of HMGA2· DNA Complexes Using Trapped Ion Mobility Spectrometry–Mass Spectrometry
K Jeanne Dit Fouque, SN Sipe… - Journal of the …, 2022 - ACS Publications
The mammalian high mobility group protein AT-hook 2 (HMGA2) is an intrinsically
disordered DNA-binding protein expressed during embryogenesis. In the present work, the …
disordered DNA-binding protein expressed during embryogenesis. In the present work, the …
[HTML][HTML] Binding the mammalian high mobility group protein AT-hook 2 to AT-rich deoxyoligonucleotides: enthalpy-entropy compensation
S Joynt, V Morillo, F Leng - Biophysical journal, 2009 - cell.com
HMGA2 is a DNA minor-groove binding protein. We previously demonstrated that HMGA2
binds to AT-rich DNA with very high binding affinity where the binding of HMGA2 to poly (dA …
binds to AT-rich DNA with very high binding affinity where the binding of HMGA2 to poly (dA …
Specific recognition of AT-rich DNA sequences by the mammalian high mobility group protein AT-hook 2: a SELEX study
T Cui, F Leng - Biochemistry, 2007 - ACS Publications
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a transcriptional factor
involved in cell differentiation and transformation. Disruption of its normal expression pattern …
involved in cell differentiation and transformation. Disruption of its normal expression pattern …
Exploring the Conformations and Binding Location of HMGA2· DNA Complexes Using Ion Mobility Spectrometry and 193 nm Ultraviolet Photodissociation Mass …
SN Sipe, K Jeanne Dit Fouque… - Journal of the …, 2022 - ACS Publications
Although it is widely accepted that protein function is largely dependent on its structure,
intrinsically disordered proteins (IDPs) lack defined structure but are essential in proper …
intrinsically disordered proteins (IDPs) lack defined structure but are essential in proper …
The energetics of specific binding of AT-hooks from HMGA1 to target DNA
AI Dragan, JR Liggins, C Crane-Robinson… - Journal of molecular …, 2003 - Elsevier
The interaction of the second and third AT-hooks of HMGA1 (formerly HMGI/Y), which bind
selectively in the minor groove of an AT-rich DNA sequence, was studied at different …
selectively in the minor groove of an AT-rich DNA sequence, was studied at different …
[HTML][HTML] The dimerization state of the mammalian high mobility group protein AT-hook 2 (HMGA2)
L Frost, MAM Baez, C Harrilal, A Garabedian… - PLoS …, 2015 - journals.plos.org
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a chromosomal
architectural transcription factor involved in cell transformation and oncogenesis. It consists …
architectural transcription factor involved in cell transformation and oncogenesis. It consists …
[HTML][HTML] Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays
The mammalian high mobility group protein AT-hook 2 (HMGA2) is a multi-functional DNA-
binding protein that plays important roles in tumorigenesis and adipogenesis. Previous …
binding protein that plays important roles in tumorigenesis and adipogenesis. Previous …
[HTML][HTML] Peptide sequence influence on the conformational dynamics and DNA binding of the intrinsically disordered AT-hook 3 peptide
The intrinsically disordered ATHP3 was studied at native conditions and in complex with
DNA using single amino acid substitutions and high-resolution ion mobility spectrometry …
DNA using single amino acid substitutions and high-resolution ion mobility spectrometry …
[HTML][HTML] The mammalian high mobility group protein AT-Hook 2 (HMGA2): biochemical and biophysical properties, and its association with adipogenesis
The mammalian high-mobility-group protein AT-hook 2 (HMGA2) is a small DNA-binding
protein and consists of three “AT-hook” DNA-binding motifs and a negatively charged C …
protein and consists of three “AT-hook” DNA-binding motifs and a negatively charged C …