Molecular imaging of lung glucose uptake after endotoxin in mice

Z Zhou, J Kozlowski, AL Goodrich… - … of Physiology-Lung …, 2005 - journals.physiology.org
Positron emission tomographic imaging after administration of the glucose analog fluorine-
18 fluorodeoxyglucose ([18F] FDG) may be useful to study neutrophilic inflammation of the …

Positron emission tomography with [18F]fluorodeoxyglucose to evaluate neutrophil kinetics during acute lung injury

DL Chen, DP Schuster - American Journal of Physiology …, 2004 - journals.physiology.org
We measured neutrophil glucose uptake with positron emission tomographic imaging and
[18F] fluorodeoxyglucose ([18F] FDG-PET) in anesthetized dogs after intravenous oleic acid …

18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury

RS Rodrigues, FA Bozza, CJ Hanrahan… - Nuclear medicine and …, 2017 - Elsevier
Introduction Molecular imaging of the earliest events related to the development of acute
lung injury (ALI)/acute respiratory distress syndrome (ARDS) could facilitate therapeutic …

Imaging pulmonary inflammation with positron emission tomography: a biomarker for drug development

DL Chen, DP Schuster - Molecular pharmaceutics, 2006 - ACS Publications
Methods currently used to assess lung and airway inflammation are often poorly
quantitative, invasive, nonspecific, or insensitive. Positron emission tomography (PET) with …

Analysis of 2-[Fluorine-18]-Fluoro-2-deoxy-D-glucose uptake kinetics in PET studies of pulmonary inflammation

T Schroeder, MFV Melo, JG Venegas - Academic radiology, 2011 - Elsevier
Dynamic positron emission tomography (PET) imaging of the lung using the radiotracer 2-
[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG) is an emerging method to assess …

FDG-PET imaging of pulmonary inflammation in healthy volunteers after airway instillation of endotoxin

DL Chen, DB Rosenbluth, MA Mintun… - Journal of Applied …, 2006 - journals.physiology.org
Recent studies indicate that a focal, limited, inflammatory response can be safely elicited
after direct bronchial instillation of small doses of endotoxin into a single lung segment …

Micro-Autoradiographic Assessment of Cell Types Contributing to 2-Deoxy-2-[18F]Fluoro-d-Glucose Uptake During Ventilator-Induced and Endotoxemic Lung Injury

D Saha, K Takahashi, N de Prost, T Winkler… - Molecular imaging and …, 2013 - Springer
Purpose The aim of the study was to use micro-autoradiography to investigate the lung cell
types responsible for 2-deoxy-2-[18 F] fluoro-d-glucose (FDG) uptake in murine models of …

Modeling pulmonary kinetics of 2-deoxy-2-[18F] fluoro-D-glucose during acute lung injury

T Schroeder, MFV Melo, G Musch, RS Harris… - Academic radiology, 2008 - Elsevier
RATIONALE AND OBJECTIVES: Dynamic positron emission tomographic imaging of the
radiotracer 2-deoxy-2-[18F] fluoro-d-glucose (18F-FDG) is increasingly used to assess …

Dissociation between respiratory burst activity and deoxyglucose uptake in human neutrophil granulocytes: implications for interpretation of 18F-FDG PET images

HA Jones, KA Cadwallader, JF White… - Journal of Nuclear …, 2002 - Soc Nuclear Med
Neutrophil granulocytes play a key role in the pathogenesis of a wide variety of pulmonary
diseases. In many such conditions, the injury observed reflects the activation status rather …

Comparison of methods to quantitate 18F-FDG uptake with PET during experimental acute lung injury

DL Chen, MA Mintun, DP Schuster - Journal of Nuclear Medicine, 2004 - Soc Nuclear Med
PET with 18F-FDG may be useful for quantifying neutrophilic activation. We previously
demonstrated that pulmonary neutrophil sequestration could be detected during acute lung …