Cytokines stimulated by IL-33 in human skin mast cells: Involvement of NF-κB and p38 at distinct levels and potent co-operation with FcεRI and MRGPRX2
K Franke, Z Wang, T Zuberbier, M Babina - International Journal of …, 2021 - mdpi.com
The IL-1 family cytokine IL-33 activates and re-shapes mast cells (MCs), but whether and by
what mechanisms it elicits cytokines in MCs from human skin remains poorly understood …
what mechanisms it elicits cytokines in MCs from human skin remains poorly understood …
[HTML][HTML] Yin-yang of IL-33 in human skin mast cells: Reduced degranulation, but augmented histamine synthesis through p38 activation
M Babina, Z Wang, K Franke, S Guhl, M Artuc… - Journal of Investigative …, 2019 - Elsevier
Mast cells (MCs) are the principal effector cells of IgE-mediated allergy. IL-33 is released by
resident skin cells as alarmin upon tissue damage or allergen contact. Owing to their …
resident skin cells as alarmin upon tissue damage or allergen contact. Owing to their …
MK2/3 are pivotal for IL-33–induced and mast cell–dependent leukocyte recruitment and the resulting skin inflammation
S Drube, F Kraft, J Dudeck, AL Müller… - The Journal of …, 2016 - journals.aai.org
The IL-1R family member IL-33R mediates Fcε-receptor-I (FcεRI)-independent activation of
mast cells leading to NF-κB activation and consequently the production of cytokines. IL-33 …
mast cells leading to NF-κB activation and consequently the production of cytokines. IL-33 …
IL-33-mediated activation of mast cells is involved in the progression of imiquimod-induced psoriasis-like dermatitis
X Zhou, Y Hu, L Liu, L Liu, H Chen, D Huang… - Cell Communication and …, 2023 - Springer
Background Psoriasis is a chronic inflammatory dermatosis with an unclear pathogenesis.
Mast cells (MCs) can serve as a bridge between innate and adaptive immunity and are …
Mast cells (MCs) can serve as a bridge between innate and adaptive immunity and are …
The expression and regulation of interleukin-33 in human epidermal keratinocytes: a new mediator of atopic dermatitis and its possible signaling pathway
HY Du, HY Fu, DN Li, Y Qiao, QW Wang… - Journal of Interferon & …, 2016 - liebertpub.com
Interleukin (IL)-33 is a novel member of the IL-1 superfamily of cytokines that has recently
become a focal point for research into the pathogenesis of atopic dermatitis (AD). However …
become a focal point for research into the pathogenesis of atopic dermatitis (AD). However …
[HTML][HTML] IL-33 and ST2 in atopic dermatitis: expression profiles and modulation by triggering factors
T Savinko, S Matikainen, U Saarialho-Kere… - Journal of Investigative …, 2012 - Elsevier
In the acute phase of atopic dermatitis (AD), T-helper type 2 (Th2) cytokines characterize the
inflammatory response in the skin. IL-33 is a new tissue-derived cytokine, which is mainly …
inflammatory response in the skin. IL-33 is a new tissue-derived cytokine, which is mainly …
IL-10 differentially promotes mast cell responsiveness to IL-33, resulting in enhancement of type 2 inflammation and suppression of neutrophilia
S Ranjitkar, D Krajewski, C Garcia… - The Journal of …, 2024 - journals.aai.org
Mast cells (MCs) play critical roles in the establishment of allergic diseases. We recently
demonstrated an unexpected, proinflammatory role for IL-10 in regulating MC responses. IL …
demonstrated an unexpected, proinflammatory role for IL-10 in regulating MC responses. IL …
Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells
IL-33 (or IL-1F11) was recently identified as a ligand for the previously orphaned IL-1 family
receptor T1/ST2. Previous studies have established that IL-33 and T1/ST2 exert key …
receptor T1/ST2. Previous studies have established that IL-33 and T1/ST2 exert key …
IL-33 can promote survival, adhesion and cytokine production in human mast cells
IL-33 is a recently identified member of the IL-1 family of molecules, which also includes IL-1
and IL-18. IL-33 binds to the receptor, T1/ST2/IL-1R4, and can promote cytokine secretion by …
and IL-18. IL-33 binds to the receptor, T1/ST2/IL-1R4, and can promote cytokine secretion by …
IL-33 is regulated by TNF-α in normal and psoriatic skin
A Balato, R Di Caprio, L Canta, M Mattii… - Archives of …, 2014 - Springer
Abstract Interleukin-33 (IL-33) is the most recently discovered IL-1 family member.
Considered an endogenous “alarmin” released by necrotic cells in response to tissue injury …
Considered an endogenous “alarmin” released by necrotic cells in response to tissue injury …