Taste preference for fatty acids is mediated by GPR40 and GPR120

C Cartoni, K Yasumatsu, T Ohkuri… - Journal of …, 2010 - Soc Neuroscience
The oral perception of fat has traditionally been considered to rely mainly on texture and
olfaction, but recent findings suggest that taste may also play a role in the detection of long …

G protein–coupled receptors in human fat taste perception

MM Galindo, N Voigt, J Stein, J van Lengerich… - Chemical …, 2012 - academic.oup.com
In contrast to carbohydrates and proteins, which are detected by specialized taste receptors
in the forms of their respective building blocks, sugars, and l-amino acids, the third …

Fatty acid taste quality information via GPR120 in the anterior tongue of mice

K Yasumatsu, S Iwata, M Inoue… - Acta Physiologica, 2019 - Wiley Online Library
Aim To elucidate whether fatty acid taste has a quality that does not overlap with other
primary qualities, we investigated potential neuron types coding fatty acid information and …

Cell signaling mechanisms of oro-gustatory detection of dietary fat: advances and challenges

TA Gilbertson, NA Khan - Progress in lipid research, 2014 - Elsevier
CD36 and two G-protein coupled receptors (GPCR), ie, GPR120 and GPR40, have been
implicated in the gustatory perception of dietary fats in rodents. These glycoproteins are …

GPR expression in the rat taste bud relating to fatty acid sensing

S Matsumura, T Mizushige, T Yoneda… - Biomedical …, 2007 - jstage.jst.go.jp
We investigated the expression of G protein-coupled receptor GPR40 and GPR120 in the rat
tongue. Using reverse transcription polymerase chain reaction, we detected a significant …

The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference

C Martin, P Passilly-Degrace, D Gaillard, JF Merlin… - PLoS …, 2011 - journals.plos.org
Background Recent studies in rodents and humans suggest that the chemoreception of long-
chain fatty acids (LCFA) in oral cavity is involved in the spontaneous preference for fatty …

A systematic review of the biological mediators of fat taste and smell

RB Jaime-Lara, BE Brooks, C Vizioli… - Physiological …, 2023 - journals.physiology.org
Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly
palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is …

Colocalization of GPR120 with phospholipase-Cβ2 and α-gustducin in the taste bud cells in mice

S Matsumura, A Eguchi, T Mizushige, N Kitabayashi… - Neuroscience …, 2009 - Elsevier
A recent study has demonstrated that the G-protein coupled receptor GPR120 is expressed
in the taste bud cells in rats. In this study, we have identified the types of taste cell that …

Transient receptor potential channel type M5 is essential for fat taste

P Liu, BP Shah, S Croasdell… - Journal of …, 2011 - Soc Neuroscience
Until recently, dietary fat was considered to be tasteless, and its primary sensory attribute
was believed to be its texture (;). However, a number of studies have demonstrated the …

Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity

C Martin, P Passilly-Degrace, M Chevrot, D Ancel… - Journal of lipid …, 2012 - ASBMB
Glucagon-like peptide-1 (GLP-1) signaling modulates sweet-taste sensitivity in the mouse.
Because circumvallate papillae (CVPs) express both GLP-1 and its receptor, a local …