Extensive research in humans and animal models has begun to unravel the complex
mechanisms that drive the immunopathogenesis of periodontitis. Neutrophils mount an early …

Dendritic cells consist of a family of potent antigen-capture and antigen-presenting cells that
infiltrate the mucosa, skin, and most organs of the body. The dendritic cell subsets that …

T cells, particularly CD 4+ T cells, play a central role in both progression and control of
periodontal disease, whereas the contribution of the various CD 4+ T helper subsets to …

Of the many cells that constitute the innate arm of the immune system, perhaps the least is
known about dendritic cells. This is due to their rarity in vivo, the lack of a cell marker …

Background: Dendritic cells are characterized by shape, structure, and membrane molecule
expression; they contact T lymphocytes to present antigens and stimulate plasma cell …

As the aging population grows, chronic age-related bone degenerative diseases become
more prevalent and severe. One such disease, periodontitis (PD), rises to 70.1% prevalence …

As the most potent cells activating and polarizing naive T cells, dendritic cells (DCs) are of
major importance in the induction of immunity and tolerance. DCs are a heterogeneous …

Previous studies have analyzed the lymphoid and myeloid foci within the gingival mucosa in
health and chronic periodontitis (CP); however, the principal APCs responsible for the …

The mucosal lining of the respiratory and digestive systems contains the largest and most
complex immune system in the body, but surprisingly little is known of the immune system …

Chronic inflammatory periodontal disease is caused by host immune responses to
periodontal microorganisms. Although periodontal disease seems to progress locally in the …