The family of interferon (IFN) proteins has now more than reached the potential envisioned
by early discovering virologists: IFNs are not only antivirals with a spectrum of clinical …

The interferons (IFNs) are a family of cytokines that protect against disease by direct effects
on target cells and by activating immune responses. The production and actions of IFNs are …

This review article addresses the largely unanticipated convergence of two landmark
discoveries. The first is the discovery of interferons, critical signaling molecules for all …

Interferons (IFNs) are a family of pleiotropic cytokines that typically exhibit antiviral,
antiproliferative, antitumor, and immunomodulatory properties. While their complex …

After several decades of intense clinical research, the great promise of Type I interferons
(IFN1) as the anticancer wonder drugs that could cure or, at the very least, curb the …

The first report on the antitumor effects of interferon α/β (IFN-I) in mice was published 50
years ago. IFN-α were the first immunotherapeutic drugs approved by the FDA for clinical …

Type I interferons (IFN-I) were first discovered as an antiviral factor by Isaacs and
Lindenmann in 1957, but they are now known to also modulate innate and adaptive …

Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant
transformation, tumor progression, and response to therapy. On the one hand, robust, acute …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …