The characteristic desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a
key contributor to its lethality. This stromal microenvironment is populated by cancer …

Pancreatic ductal adenocarcinoma remains one of the most challenging human cancers.
Desmoplasia is predominant in this disease exhibiting a strong stromal reaction with an …

Background Metastasis occurs in the majority of pancreatic ductal adenocarcinoma (PDAC)
patients at diagnosis or following resection. Patients with liver metastasis and those with …

Cancer-associated fibroblasts (CAFs) are one of the most significant components in the
tumour microenvironment (TME), where they can perform several protumourigenic functions …

Cancer stem cells (CSCs) play an important role in the clonogenic growth and metastasis of
pancreatic ductal adenocarcinoma (PDAC). A hallmark of PDAC is the desmoplastic …

The tumor microenvironment is of crucial importance affecting treatment and prognosis. High
degree of carcinoma-associated fibroblast (CAF) infiltration occurs in pancreatic cancer …

Pancreatic ductal adenocarcinoma (PDA) is characterized by a dense stroma consisting of a
prevalence of activated fibroblasts whose functional contributions to pancreatic …

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer. The poor prognosis
calls for a more detailed understanding of disease biology in order to pave the way for the …

Objective Cancer-associated fibroblasts (CAFs) play an important role in the progression of
pancreatic ductal adenocarcinoma (PDAC) by promoting tumor cell migration and drug …

The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its
mechanism in initiating distant metastasis is not well understood. Here, we generated a …