[HTML][HTML] Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer
KM Boehm, EA Aherne, L Ellenson, I Nikolovski… - Nature cancer, 2022 - nature.com
Patients with high-grade serous ovarian cancer suffer poor prognosis and variable response
to treatment. Known prognostic factors for this disease include homologous recombination …
to treatment. Known prognostic factors for this disease include homologous recombination …
[HTML][HTML] Time to recurrence and survival in serous ovarian tumors predicted from integrated genomic profiles
Background Serous ovarian cancer (SeOvCa) is an aggressive disease with differential and
often inadequate therapeutic outcome after standard treatment. The Cancer Genome Atlas …
often inadequate therapeutic outcome after standard treatment. The Cancer Genome Atlas …
[HTML][HTML] Ovarian cancer beyond imaging: integration of AI and multiomics biomarkers
High-grade serous ovarian cancer is the most lethal gynaecological malignancy. Detailed
molecular studies have revealed marked intra-patient heterogeneity at the tumour …
molecular studies have revealed marked intra-patient heterogeneity at the tumour …
[HTML][HTML] Integrating genomic, epigenomic, and transcriptomic features reveals modular signatures underlying poor prognosis in ovarian cancer
Ovarian cancer has a poor prognosis, with different outcomes for different patients. The
mechanism underlying this poor prognosis and heterogeneity is not well understood. We …
mechanism underlying this poor prognosis and heterogeneity is not well understood. We …
[HTML][HTML] Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long-and short-term survivors
Background Patients diagnosed with high-grade serous ovarian cancer (HGSOC) who
received initial debulking surgery followed by platinum-based chemotherapy can …
received initial debulking surgery followed by platinum-based chemotherapy can …
[HTML][HTML] Harnessing pandemonium: the clinical implications of tumor heterogeneity in ovarian cancer
SP Blagden - Frontiers in oncology, 2015 - frontiersin.org
Heterogeneity has emerged as a key feature of ovarian cancer between different ovarian
cancer subtypes; within single ovarian cancer subtypes; and within individual patient tumors …
cancer subtypes; within single ovarian cancer subtypes; and within individual patient tumors …
[HTML][HTML] Spatially resolved transcriptomics of high-grade serous ovarian carcinoma
Bulk and single-cell RNA sequencing do not provide full characterization of tissue spatial
diversity in cancer samples, and currently available in situ techniques (multiplex …
diversity in cancer samples, and currently available in situ techniques (multiplex …
[HTML][HTML] Molecular analysis of clinically defined subsets of high-grade serous ovarian cancer
The diversity and heterogeneity within high-grade serous ovarian cancer (HGSC), which is
the most lethal gynecologic malignancy, is not well understood. Here, we perform …
the most lethal gynecologic malignancy, is not well understood. Here, we perform …
[HTML][HTML] Evolutionary states and trajectories characterized by distinct pathways stratify patients with ovarian high grade serous carcinoma
Ovarian high-grade serous carcinoma (HGSC) is typically diagnosed at an advanced stage,
with multiple genetically heterogeneous clones existing in the tumors long before …
with multiple genetically heterogeneous clones existing in the tumors long before …
[HTML][HTML] Genetic characterization of primary and metastatic high-grade serous ovarian cancer tumors reveals distinct features associated with survival
EN Kotnik, MM Mullen, NC Spies, T Li… - Communications …, 2023 - nature.com
High-grade serous ovarian cancer (HGSC) is the most lethal histotype of ovarian cancer and
the majority of cases present with metastasis and late-stage disease. Over the last few …
the majority of cases present with metastasis and late-stage disease. Over the last few …