Mechanisms of oncogenesis by HTLV-1 Tax

S Mohanty, EW Harhaj - Pathogens, 2020 - mdpi.com
The human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATLL), a neoplasm of CD4+ CD25+ T cells that occurs in 2–5% of …

HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

R Currer, R Van Duyne, E Jaworski, I Guendel… - Frontiers in …, 2012 - frontiersin.org
Human T-cell lymphotropic virus type 1 (HTLV-1) has been identified as the causative agent
of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic …

HTLV-1 infection and adult T-cell leukemia/lymphoma—a tale of two proteins: tax and HBZ

CZ Giam, OJ Semmes - Viruses, 2016 - mdpi.com
HTLV-1 (Human T-cell lymphotropic virus type 1) is a complex human delta retrovirus that
currently infects 10–20 million people worldwide. While HTLV-1 infection is generally …

Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis

M Higuchi, M Fujii - Retrovirology, 2009 - Springer
While the human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell
leukemia/lymphoma (ATL), to date, its close relative HTLV-2 is not associated with ATL or …

Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis

Z Qu, G Xiao - Viruses, 2011 - mdpi.com
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of adult T-cell
leukemia/lymphoma (ATL), whereas the highly related HTLV-2 is not associated with ATL or …

Regulation of HTLV-1 transformation

KJ Ernzen, AR Panfil - Bioscience reports, 2022 - portlandpress.com
Human T-cell leukemia virus type 1 (HTLV-1) is the only identified oncogenic human
retrovirus. HTLV-1 infects approximately 5–10 million people worldwide and is the infectious …

NF‐κB signaling mechanisms in HTLV‐1‐induced adult T‐cell leukemia/lymphoma

EW Harhaj, CZ Giam - The FEBS journal, 2018 - Wiley Online Library
The human T‐cell leukemia virus type 1 (HTLV‐1) is a complex deltaretrovirus linked to
adult T‐cell leukemia/lymphoma (ATLL), a fatal CD 4+ malignancy in 3–5% of infected …

The HTLV-1 tax interactome

M Boxus, JC Twizere, S Legros, JF Dewulf, R Kettmann… - Retrovirology, 2008 - Springer
The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant
of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling …

HTLV deregulation of the NF-κB pathway: An update on tax and antisense proteins role

S Fochi, S Mutascio, U Bertazzoni, D Zipeto… - Frontiers in …, 2018 - frontiersin.org
Human T-cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell
leukemia (ATL), an aggressive CD4+/CD25+ T-cell malignancy and of a severe …

Impact of host immunity on HTLV-1 pathogenesis: potential of Tax-targeted immunotherapy against ATL

M Kannagi, A Hasegawa, Y Nagano, S Kimpara… - Retrovirology, 2019 - Springer
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL),
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and other …