Aging is a complex process characterized by a myriad of physiological changes, including
alterations in the immune system termed immunosenescence. It exerts profound effects on …

As we age, the immune system undergoes a process of senescence accompanied by the
increased production of proinflammatory cytokines, a chronic subclinical condition named as …

Alzheimer's disease (AD) is a chronic multifactorial and complex neuro-degenerative
disorder characterized by memory impairment and the loss of cognitive ability, which is a …

The incidence of age‐related dementia is growing with increased longevity, yet there are
currently no disease‐modifying therapies for these devastating disorders. Studies over the …

Aging involves progressive deterioration away from homeostasis. Whereas the healthy adult
brain maintains neuroimmune cells in a surveillant and homeostatic state, aged glial cells …

The aging of the global population poses significant scientific challenges. Moreover, the
biological process of aging is the most significant risk factor for most chronic illnesses; …

Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …

Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and
contribute to neurodegenerative pathology. Although microglia have been the focus of work …

In recent years, the inter-relationship between the innate immune system and the central
nervous system (CNS) has moved to the forefront of biomedical research, with the discovery …

Neurodegenerative diseases are a major cause of death and disability worldwide and are
influenced by many factors including age, genetics, and injuries. While these diseases are …