Injectable hydrogel imbibed with camptothecin-loaded mesoporous silica nanoparticles as an implantable sustained delivery depot for cancer therapy

JM Jung, YL Jung, SH Kim, DS Lee… - Journal of Colloid and …, 2023 - Elsevier
In recent years, injectable stimuli-sensitive hydrogels are employed as suitable drug delivery
carriers for the release of various anti-cancer drugs. However, large pore size of the …

Hollow mesoporous silica nanoparticles facilitated drug delivery via cascade pH stimuli in tumor microenvironment for tumor therapy

J Liu, Z Luo, J Zhang, T Luo, J Zhou, X Zhao, K Cai - Biomaterials, 2016 - Elsevier
To efficiently deliver anti-cancer drug to tumor site and reduce its toxic side effects on normal
tissues, a polyethylene glycol (PEG) shielding and tumor microenvironment triggering …

Dual-pH-sensitive mesoporous silica nanoparticle-based drug delivery system for tumor-triggered intracellular drug release

H Chen, Y Kuang, R Liu, Z Chen, B Jiang, Z Sun… - Journal of Materials …, 2018 - Springer
Reducing the side effects and improving the drug utilization are important work in anti-
cancer drug delivery. In this paper, a novel dual-pH-sensitive drug delivery system was …

Natural gelatin capped mesoporous silica nanoparticles for intracellular acid-triggered drug delivery

Z Zou, D He, X He, K Wang, X Yang, Z Qing, Q Zhou - Langmuir, 2013 - ACS Publications
This paper proposed a natural gelatin capped mesoporous silica nanoparticles (MSN@
Gelatin) based pH-responsive delivery system for intracellular anticancer drug controlled …

A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy

L Huang, J Liu, F Gao, Q Cheng, B Lu… - Journal of Materials …, 2018 - pubs.rsc.org
In this study, a novel drug delivery system (HMSNs-SS-HA) based on hollow mesoporous
silica nanoparticles (HMSNs) was developed for delivering anticancer drugs (eg …

Polysaccharides/mesoporous silica nanoparticles hybrid composite hydrogel beads for sustained drug delivery

Y Hu, X Dong, L Ke, S Zhang, D Zhao, H Chen… - Journal of Materials …, 2017 - Springer
A simple and effective route was established to regulate the drug release kinetics of
hydrogels through a combination method of the polysaccharides matrix which delivers the …

In situ-forming gels loaded with stimuli-responsive gated mesoporous silica nanoparticles for local sustained drug delivery

C De La Torre, C Coll, A Ultimo, F Sancenón… - Pharmaceutics, 2023 - mdpi.com
A novel combination of in situ-forming hydrogels of hyaluronic acid with gated mesoporous
materials was developed to design depots for local sustained release of chemotherapeutics …

pH and redox dual stimulate-responsive nanocarriers based on hyaluronic acid coated mesoporous silica for targeted drug delivery

JT Lin, JK Du, YQ Yang, L Li, DW Zhang… - Materials Science and …, 2017 - Elsevier
In this work, we developed a drug-conjugated nanocarrier with “zero premature release”
property for actively targeted drug delivery. The pH and redox dual-responsive nanocarrier …

Hyaluronic acid encapsulated aminated mesoporous silica nanoparticles for pH‐responsive delivery of methotrexate and release kinetics

Q Rui, ZZ Yin, W Cai, J Li, D Wu… - Bulletin of the Korean …, 2022 - Wiley Online Library
A simple drug controlled delivery system is facilely designed for pH‐responsive delivery of
methotrexate (MTX), an anticancer drug. Aminated mesoporous silica nanoparticles …

Thermosensitive Hydrogel-Functionalized Mesoporous Silica Nanoparticles for Parenteral Application of Chemotherapeutics

C Voycheva, M Slavkova, T Popova, D Tzankova… - Gels, 2023 - mdpi.com
Hydrogels can offer many opportunities for drug delivery strategies. They can be used on
their own, or their benefits can be further exploited in combination with other nanocarriers …