Sepsis‐induced acute kidney injury (SI‐AKI) is common and associated with high mortality.
Survivors are at increased risk of chronic kidney disease. The precise mechanism …

Acute kidney injury (AKI) is a common and devastating pathologic condition, associated with
considerable high morbidity and mortality. Although significant breakthroughs have been …

Acute kidney injury (AKI) is one of the most important complications in hospitalized patients
and its pathomechanisms are not completely elucidated. We hypothesize that signaling via …

Acute renal failure is a grave complication of systemic gram‐negative sepsis. The
pathophysiological mechanisms of sepsis leading to kidney injury result in part from …

Mortality from sepsis has remained high despite recent advances in supportive and targeted
therapies. Toll-like receptors (TLRs) sense bacterial products and stimulate pathogenic …

Acute kidney injury (AKI) is a progressive renal complication which significantly affects the
patient's life with huge economic burden. Untreated acute kidney injury eventually …

Ischemic acute kidney injury (AKI) triggers an inflammatory response which exacerbates
injury that requires increased expression of endothelial adhesion molecules. To study this …

Acute kidney injury (AKI) is an important health problem, affecting 13.3 million
individuals/year. It is associated with increased mortality, mainly in low-and middle-income …

OBJECTIVE: To determine the involvement of Toll-like receptor (TLR) 2, TLR9, and TLR2+ 9
in renal ischemia/reperfusion (I/R) injury. METHODS: Mice with gene knock-out of TLR2 …

Toll-like receptors (TLRs) can detect endogenous danger molecules released upon tissue
injury resulting in the induction of a proinflammatory response. One of the TLR family …