ContextSecond-trimester prenatal ultrasound is widely used in an attempt to detect Down
syndrome in fetuses, but the accuracy of this method is unknown. ObjectiveTo determine the …

Down syndrome (trisomy 21) is the most common chromosomal abnormality among liveborn
infants in the United States, with an incidence of 1/700 to 1/1000 births. Its incidence rises …

Objective To determine the association between second trimester ultrasound findings
(genetic sonogram) and the risk of Down syndrome. Methods Prospective population‐based …

This review summarizes the development, history and use of second‐trimester sonographic
markers for the detection of fetal Down syndrome over three decades. Starting with the …

Objective To describe and test a method of individual risk assessment for fetal Down's
syndrome based on maternal age and second‐trimester ultrasound findings. Design A case …

Sonographic markers for Down's syndrome have been useful in the identification of affected
fetuses. In this study, we evaluated the accuracy of an expanded scoring index that included …

The Genetic Sonogram is an ultrasound examination done on second trimester fetuses that
not only evaluates the fetus for structural malformations, but also searches for the …

Objective. To determine the risk of Down syndrome in fetuses with sonographic markers
using the Bayes theorem and likelihood ratios. Methods. We prospectively evaluated the …

OBJECTIVE: Our purpose was to evaluate the usefulness of prenatal ultrasonography
among women with a positive screen for fetal Down syndrome on the basis of three …

Mid‐trimester soft markers have been linked with Down syndrome and other aneuploidies.
There are many other prenatal screening tests available with better detection rates for Down …