Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

Tumor progression, including metastasis, is significantly influenced by factors in the tumor
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …

Although many studies have focused on oncology and therapeutics in cancer, cancer
remains one of the leading causes of death worldwide. Due to the unclear molecular …

Cancer kills millions of individuals every year all over the world (Global Cancer
Observatory). The physiological and biomechanical processes underlying the tumor are still …

Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …

More than 90% of cancer-related deaths can be attributed to the occurrence of metastatic
diseases. Recent studies have highlighted the importance of the multicellular, biochemical …

The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …

Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …

Over the past 15 years, the field of oncology research has witnessed significant progress in
the development of new cell culture models, such as tumor-on-chip (ToC) systems. In this …

Over the past six decades the inflation-adjusted cost to bring a new drug to market has been
increasing constantly and doubles every 9 years–now reaching in excess of $2.5 billion …