Cytochromes P450 (CYPs) constitute a family of enzymes that can be found in the
endoplasmic reticulum (ER), mitochondria or the cell surface of the cells. CYPs are …

Cytochrome P450 (CYP) enzymes are responsible for the metabolism of many exogenous
and endogenous compounds. CYPs are abundant in the liver and are also expressed in …

The regulation of brain cytochrome P450 enzymes (CYPs) is different compared with
respective hepatic enzymes. This may result from anatomical bases and physiological …

The metabolism of xenobiotics in human brain constitutes a field of recent intensive research
in relation to the potential implications in the pharmacological effect of drugs acting on the …

The current state of knowledge indicates that the cerebral cytochrome P450 (CYP) plays an
important role in the endogenous metabolism in the brain. Different CYP isoenzymes …

Advances in a multitude of disciplines support an emerging role for cytochrome P450
enzymes and their metabolic substrates and end-products in the pathogenesis and …

After many frustrating decades of unsuccessful attempts to characterize the isoforms of P450
in the brain, several scientific breakthroughs in the 80s and 90s have resulted in major …

P450s in the human brain were originally considered unlikely to contribute significantly to
the clearance of drugs and other xenobiotic chemicals, since their overall expression was a …

Highlights•Brain P450 enzymes constitute an extra-hepatic line of drug metabolism.•P450s
expressed in brain cells contribute to neurotoxicity or neuroprotection.•Neurovascular P450 …

Cytochrome P450 (CYP) enzymes catalyse phase I metabolic reactions of psychotropic
drugs. The main isoenzymes responsible for this biotransformation are CYP1A2, CYP2D6 …