Cataract-associated gene discovery in human and animal models have informed on key
aspects of human lens development, homeostasis and pathology. Additionally, in vitro …

The discovery of cytosolic RNA granule (RG) component proteins associated with human
cataract has initiated investigations on post-transcriptional mechanisms of gene expression …

Isolated or syndromic congenital cataracts are heterogeneous developmental defects,
making the identification of the associated genes challenging. In the past, mouse lens …

Although successful in identifying new cataract-linked genes, the previous version of the
database iSyTE (i ntegrated Sy stems T ool for E ye gene discovery) was based on …

Purpose Age-related cataract is a multi-factorial disease with a poorly understood etiology.
Numerous studies provide evidence that the human eye lens has evolved specific regulatory …

Over the past several decades, the biology of the developing lens has been investigated
using molecular genetics-based approaches in various vertebrate model systems. These …

Elucidation of both the molecular composition and organization of the ocular lens is a
prerequisite to understand its development, function, pathology, regenerative capacity, as …

Purpose.: To facilitate the identification of genes associated with cataract and other ocular
defects, the authors developed and validated a computational tool termed iSyTE (i ntegrated …

The transparent ocular lens in the anterior chamber of the eye is responsible for fine
focusing of light onto the retina. The lens is entirely cellular with bulk of the tissue composed …

Purpose: In order to identify specific genes that may play important roles in maintaining the
specialized functions of lens epithelial and fiber cells, we have analyzed the global gene …