Notch pathway signaling is implicated in several human cancers. Aberrant activation and
mutations of Notch signaling components are linked to tumor initiation, maintenance, and …

Dysregulated Notch signaling has been implicated in numerous human diseases, including
a broad spectrum of cancers. Mutations in Notch1 are prevalent in T-cell acute lymphoblastic …

The Notch signaling pathway represents a critical component in the molecular circuits that
control cell fate during development. Aberrant activation of this pathway contributes to …

Notch is a key player in various developmental processes during the embryonic stage as
well as in regulating tissue homeostasis, cell differentiation, and stem cell maintenance in …

Notch signaling plays a key role in the normal development of many tissues and cell types,
through diverse effects on differentiation, survival, and/or proliferation that are highly …

NOTCH-ligand interaction is a highly conserved mechanism that regulates specific cell fate
decision during development. In addition to its functions in developmental and cell …

A metaphor for cancer is normal development gone awry. All tissues in the body arise from
embryonic stem cells that gradually give rise to specialized cells. Cancer resembles a case …

Notch signaling controls cell fate decisions including during development and stem cell
renewal and differentiation in many postnatal tissues. Increasing evidence suggests that the …

The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch
signaling pathway is one of the most commonly activated signaling pathways in cancer …

The Notch family consists of four highly conserved transmembrane receptors. The release of
the active intracellular domain requires the enzymatic activity of γ-secretase. Notch is …