Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

The biosynthesis of steroid hormones requires the coordinated expression of the enzymes
that comprise the pathways via which specific hormones are synthesized. These pathways …

Until the mid-1980s studies of steroidogenesis largely depended on identifying steroid
structures and measuring steroid concentrations in body fluids. The molecular biology …

The enzymes and pathways of steroidogenesis are familiar to most endocrinologists, but the
biochemistry and molecular biology of these processes are still being studied. This chapter …

Introduction S TEROID hormones are familiar clinically and physiologically as regulators of
physiological processes. Five groups of steroid hormones are generally recognized …

In the pathways of steroid hormone biosynthesis there are two major types of enzymes:
cytochromes P450 and other steroid oxidoreductases. This review presents an overview of …

Significant advances have taken place in our knowledge of the enzymes involved in steroid
hormone biosynthesis since the last comprehensive review in 1988. Major developments …

Cytochrome P450 (CYP) and hydroxysteroid dehydrogenase enzymes are involved in the
conversion of cholesterol to steroid hormones. These enzymes are primarily expressed in …

The amino acid sequences of two steroidogenic enzymes, P450c17 (steroid 17α-
hydroxylase/17, 20 lyse) and P450c21 (steroid 21-hydroxylase), are only 28.9% identical …

Steroid hormones are synthesized by a complex array of 10 enzymes. The genes for each of
these have now been cloned, and previous work has determined the regional chromosomal …