The source of the inhibitory levels of cAMP that maintain oocytes meiotically arrested is
under controversy. A model for regulation of the meiotic division that suggests the transfer of …

The original model for regulation of oocyte maturation proposed by us in 1978 postulated
that gap junction-mediated transmission of cAMP from the follicle cells to the oocyte inhibits …

Mammalian oocytes grow and undergo meiosis within ovarian follicles. Oocytes are arrested
at the first meiotic prophase, held in meiotic arrest by the surrounding follicle cells until a …

Meiotically arrested mammalian oocytes are stimulated to resume meiosis by LH. This
response, which can be reversed by elevation of intraoocyte cAMP levels, is associated with …

[Frontiers in Bioscience S5, 451-477, January 1, 2013] Oocyte Maturation: A story of arrest and
release Aritro Sen1, Francesco C Page 1 [Frontiers in Bioscience S5, 451-477, January 1 …

The molecular and structural changes in the follicle triggered by the gonadotropin luteinizing
hormone (LH) at ovulation require complex interactions between somatic cells and the …

The signaling pathway by which luteinizing hormone (LH) acts on the somatic cells of
vertebrate ovarian follicles to stimulate meiotic resumption in the oocyte requires a decrease …

Mammalian oocytes reach prophase of first meiosis around the time of birth, and remain at
this stage for months or years, depending on the species. Only after puberty will the fully …

In mammalian oocytes, the maintenance of meiotic prophase I arrest prior to the surge of LH
that stimulates meiotic maturation depends on a high level of cAMP within the oocyte. In …

The maintenance of meiotic prophase arrest in fully grown vertebrate oocytes depends on
the activity of a Gs G-protein that activates adenylyl cyclase and elevates cAMP, and in the …