Pamabrom is a diuretic that is effective in treating premenstrual syndrome and primary
dysmenorrhea. The aim of this study was to examine the effect of metformin and modulators …

The aim of this study was to examine if the peripheral antinociception of α-bisabolol involves
the participation of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) synthesis …

In view of the scarce information about the analgesic mechanism of κ-opioid receptor
agonists, the objective of the present study was to determine whether nitric oxide (NO) is …

The aim of this study was to examine if the peripheral antinociceptive effects of the opioid
agonist/antagonist nalbuphine and buprenorphine involve the sequential participation of …

Despite the classical peripheral pronociceptive effect of noradrenaline (NA), recently studies
showed the involvement of NA in antinociceptive effect under immune system interaction. In …

The involvement of the nitric oxide (NO)/cyclic GMP pathway in the molecular mechanisms
of antinociceptive drugs like morphine has been previously shown by our group …

The involvement of nitric oxide (NO), cyclic GMP and ATP-sensitive K+ channels in the
antinociceptive effect of ketorolac was assessed using the formalin test in the rat. Local …

BACKGROUND: The involvement of the l-arginine/nitric oxide (NO)/cyclic guanosine
monophosphate (cGMP) pathway in antinociception has been implicated as a molecular …

There is evidence that local peripheral administration of morphine produces antinociception
through the activation of the nitric oxide (NO)-cyclic GMP-K+ channels pathway. Therefore …

The aim of this study was to examine if the peripheral antinociceptive effects of diclofenac
and indomethacin involve the sequential participation of NO and cGMP synthesis followed …