Paraoxonase genes and disease
RA Hegele - Annals of Medicine, 1999 - Taylor & Francis
The paraoxonase gene family contains at least three members, including PON1, PON2 and
PON3, which are located on chromosome 7q21. 3-22.1. Until recently, there has been little …
PON3, which are located on chromosome 7q21. 3-22.1. Until recently, there has been little …
Mutations in the human paraoxonase 1 gene: frequencies, allelic linkages, and association with coronary artery disease
I Cascorbi, M Laule, PM Mrozikiewicz… - Pharmacogenetics …, 1999 - journals.lww.com
Oxidative damage is a major cause of atherosclerosis. Since human paraoxonase has been
postulated as a factor which plays a role in protection from low density lipoprotein oxidation …
postulated as a factor which plays a role in protection from low density lipoprotein oxidation …
PON2 gene variants are associated with clinical manifestations of cardiovascular disease in familial hypercholesterolemia patients
FR Leus, M Zwart, JJP Kastelein, HAM Voorbij - Atherosclerosis, 2001 - Elsevier
Paraoxonase is an enzyme associated with the high-density lipoprotein (HDL) particle. It
catalyses the hydrolysis of organophosphates and protects LDL from oxidative modification …
catalyses the hydrolysis of organophosphates and protects LDL from oxidative modification …
The paraoxonase gene family and atherosclerosis
CJ Ng, DM Shih, SY Hama, N Villa, M Navab… - Free radical biology and …, 2005 - Elsevier
Epidemiologic, genetic, and biochemical studies support an antiatherogenic role for
paraoxonase (PON) 1. While the precise mechanism by which PON1 protects against the …
paraoxonase (PON) 1. While the precise mechanism by which PON1 protects against the …
Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids
ST Reddy, DJ Wadleigh, V Grijalva, C Ng… - … , and vascular biology, 2001 - Am Heart Assoc
Paraoxonase-1 (PON1) is a secreted protein associated primarily with high density
lipoprotein (HDL) and participates in the prevention of low density lipoprotein (LDL) …
lipoprotein (HDL) and participates in the prevention of low density lipoprotein (LDL) …
[HTML][HTML] Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2
CJ Ng, N Bourquard, V Grijalva, S Hama… - Journal of Biological …, 2006 - ASBMB
Paraoxonases (PONs) are a family of proteins that may play a significant role in providing
relief from both toxic environmental chemicals as well as physiological oxidative stress …
relief from both toxic environmental chemicals as well as physiological oxidative stress …
Does paraoxonase play a role in susceptibility to cardiovascular disease?
M Aviram - Molecular Medicine Today, 1999 - cell.com
Human serum paraoxonase (PON1) is an esterase that is bound to high-density lipoproteins
(HDLs). It can hydrolyze organophosphates and its activity is inversely related to …
(HDLs). It can hydrolyze organophosphates and its activity is inversely related to …
Paraoxonase and atherosclerosis-related cardiovascular diseases
DA Chistiakov, AA Melnichenko, AN Orekhov… - Biochimie, 2017 - Elsevier
In humans, three paraoxonase (PON1, PON2, and PON3) genes are clustered on
chromosome 7 at a locus that spans a distance around 170 kb. These genes are highly …
chromosome 7 at a locus that spans a distance around 170 kb. These genes are highly …
The three-gene paraoxonase family: physiologic roles, actions and regulation
LP Précourt, D Amre, MC Denis, JC Lavoie, E Delvin… - Atherosclerosis, 2011 - Elsevier
The paraoxonase (PON) gene family is composed of three members (PON1, PON2, PON3)
that share considerable structural homology and are located adjacently on chromosome 7 in …
that share considerable structural homology and are located adjacently on chromosome 7 in …
Paraoxonase 1 and atherosclerosis: is the gene or the protein more important?
M Mackness, B Mackness - Free Radical Biology and Medicine, 2004 - Elsevier
The oxidation of low-density lipoprotein (LDL) is centrally involved in the initiation and
progression of atherosclerosis. High-density lipoprotein (HDL) paraoxonase 1 (PON1) …
progression of atherosclerosis. High-density lipoprotein (HDL) paraoxonase 1 (PON1) …