In this review we examine the mechanisms (causes) underlying the increased glucose
consumption observed in tumors within a teleological context (consequences). In other …

Malignant cells characteristically exhibit altered metabolic patterns when compared with
normal mammalian cells with increased reliance on anaerobic metabolism of glucose to …

Clinical imaging of primary and metastatic cancers with Fluoro deoxy-d-Glucose Positron
Emission Tomography (FdG PET) has clearly demonstrated that increased glucose flux …

Purpose: Low extracellular pH is a hallmark of solid tumors. It has long been thought that this
acidity is mainly attributable to the production of lactic acid. In this study, we tested the …

Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Molecular imaging of tumor metabolism has gained considerable interest, since preclinical
studies have indicated a close relationship between the activation of various oncogenes and …

The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This
perception has since become the rationale that drives a considerable proportion of basic …

The cancer cell phenotype has been summarized in six hallmarks [D. Hanahan, RA
Weinberg, The hallmarks of cancer, Cell 100 (1)(2000) 57–70]. Following the conceptual …

If carcinogenesis occurs by somatic evolution, then common components of the cancer
phenotype result from active selection and must, therefore, confer a significant growth …

Cancer is a disease at the cellular level involving heritable disorders in cellular control
mechanism. Cancer cells also need to adapt their metabolism to survive and multiply under …