Simple Summary Normal blood cells are formed in the bone marrow by a process called
hematopoiesis. This process is supported by a network of non-hematopoietic cells including …

Simple Summary The formation of normal blood cells in the bone marrow is supported by a
network of non-hematopoietic cells including connective tissue cells, blood vessel cells and …

The bone marrow constitutes an unique microenvironment for cancer cells in three specific
aspects. First, the bone marrow actively recruits circulating tumor cells where they find a …

Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting
of these cells is considered both for malignant and non-malignant diseases. We analyzed …

Maintenance of haematopoietic stem cells and differentiation of committed progenitors
occurs in highly specialized niches. The interactions of haematopoietic stem and progenitor …

Systemic factors including cytokines, cell-free nucleic acids, microvesicles, and platelets are
appreciated as important regulators of adenocarcinoma progression. Research findings …

The bone marrow microenvironment facilitates the survival, differentiation, and proliferation
of hematopoietic cells. These cells are supported by fibroblast-like bone marrow stromal …

Bone marrow mesenchymal stem cells (BM-MSCs) have the capacity for renewal and the
potential to differentiate in culture into several cell types including osteoblasts, chondrocytes …

The bone marrow (BM) is contained within the bone cavity and is the main site of
hematopoiesis, the continuous development of blood cells from immature hematopoietic …

Tumor cells with high skeletal homing affinity express numerous cell surface receptors that
bind ligands produced in bone. Upon arrival, these cells survive in the host environment …