Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance.
Metformin, a widely known anti-diabetic drug, used for patients with type 2 diabetes mellitus …

Insulin resistance plays a major role in the development of type 2 diabetes and obesity and
affects a number of biological processes such as mitochondrial biogenesis. Though …

Neurodegenerative diseases are the set of progressive, age-related brain disorders,
characterized by an excessive accumulation of mutant proteins in the certain regions of the …

The involvement of both apolipoprotein E (apoE) and mitochondria in lipid metabolism is
widely recognized, however there is surprisingly scarce data about the putative …

Nonalcoholic fatty liver disease (NAFLD) is associated with hepatic mitochondrial
dysfunction characterized by reduced ATP synthesis. We applied the 2 H 2 O-metabolic …

It has been proposed that mitochondrial dysfunction is involved in the pathogenesis of type 2
diabetes (T2D). To dissect the underlying mechanisms, we performed a multiplexed …

Mitochondrial dysfunction is closely associated with the pathogenesis of nonalcoholic
steatohepatitis (NASH). The aim of the present study was to comprehensively determine …

Mitochondrial dysfunction is recognized as a contributing factor to a number of diseases,
including chronic alcohol-induced hepatotoxicity. Although there is a detailed understanding …

OBJECTIVE To elucidate the molecular basis for mitochondrial dysfunction, which has been
implicated in the pathogenesis of diabetes complications. RESEARCH DESIGN AND …

Nonalcoholic fatty liver disease (NAFLD) is a chronic liver condition that can progress to
nonalcoholic steatohepatitis, cirrhosis and cancer. It is considered an emerging health …