A common pathway underlying a variety of neurodegenerative disorders is the aggregation
and deposition of misfolded proteins. Proteasomal inhibition has been demonstrated to …

Autophagy is a major degradation pathway where double-membrane vesicles called
autophagosomes deliver cytoplasmic content to the lysosome. Increasing evidence …

Neurons and astrocytes face unique demands on their proteome to enable proper function
and survival of the nervous system. Consequently, both cell types are critically dependent on …

Ubiquitinated inclusions are a common feature of many neurodegenerative conditions. We
have proposed that, at least in part, such inclusions may be formed due to dysfunction of the …

Investigations pursued during the last decade on neurodegenerative diseases have
revealed a common mechanism underlying the development of such diseases …

The abnormal accumulation of protein aggregates is a dominant pathological feature
common in neurodegenerative diseases. Autophagy contributes to the processing of …

Neurons have highly dynamic cellular processes for their proper functions such as cell
growth, synaptic formation, or synaptic plasticity by regulating protein synthesis and …

Macroautophagy, a major pathway for organelle and protein turnover, has been implicated
in the neurodegeneration of Alzheimer's disease (AD). The basis for the profuse …

Autophagy is considered a major bulk degradation system that helps cells to counteract
different intracellular and extracellular stress signals. Several protein complexes integrate …

Autophagy (here refers to macroautophagy) is a catabolic pathway by which large protein
aggregates and damaged organelles are first sequestered into a double-membraned …