Context: Serotonin (5-HT) may be an important regulatory agent in bone, and agents that
modify 5-HT signaling, such as selective serotonin reuptake inhibitors (SSRIs), are in …

Evidence regarding a functional serotonin (5-hydroxytryptamine) signaling system in bone
has generated considerable recent interest. The specific biochemical nature of …

Novel molecular pathways obligatory for bone health are being rapidly identified. One
pathway recently revealed involves gut-derived 5-hydroxytryptamine (5-HT) mediation of the …

An increasing number of studies suggest an association between depression and
osteoporosis. In a mouse model, depression induces bone loss, mediated by brain-to-bone …

Bone formation and bone resorption, the two processes occurring constantly and in a
balanced fashion throughout the skeleton, are regulated by signals as various as local and …

A possibility for selective serotonin reuptake inhibitors (SSRIs) to increase the risk of bone
fracture has been debated during recent years. Proposed causes include an ability for the …

The processes of bone growth and turnover are tightly regulated by the actions of various
signaling molecules, including hormones, growth factors, and cytokines. Imbalances in …

The discovery of a functional serotonin (5-hydroxytryptamine; 5-HT) transporter (5-HTT) in
bone has given rise to questions about the physiologic role of 5-HT in bone, and the …

As recent studies highlight the importance of alternative mechanisms in the control of bone
turnover, new therapeutic approaches can be envisaged for bone diseases and periodontitis …

A recent article elucidated the regulation of gut-produced serotonin by low-density
lipoprotein receptor–related protein 5 and the deleterious effect of serotonin on bone mass …