[HTML][HTML] A novel modular antigen delivery system for immuno targeting of human 6-sulfo LacNAc-positive blood dendritic cells (SlanDCs)

CC Bippes, A Feldmann, S Stamova, M Cartellieri… - PLoS …, 2011 - journals.plos.org
Background Previously, we identified a major myeloid-derived proinflammatory
subpopulation of human blood dendritic cells which we termed slanDCs (eg Schäkel et …

Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens

CM Fehres, H Kalay, SCM Bruijns… - Journal of controlled …, 2015 - Elsevier
Abstract Dendritic cells (DCs) and Langerhans cells (LC) are professional antigen
presenting cells (APCs) that initiate humoral and cellular immune responses. Targeted …

FcγRIII (CD16) equips immature 6-sulfo LacNAc–expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens

T Döbel, A Kunze, J Babatz, K Tränkner… - Blood, The Journal …, 2013 - ashpublications.org
Binding and uptake of immune complexes (ICs) via low-affinity Fcγ receptors (FcγRs) on
dendritic cells (DCs) is well known as a booster of immune responses. It can be helpful …

Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C‐type lectin receptor Langerin

L Bellmann, H Strandt, C Zelle‐Rieser… - European Journal of …, 2022 - Wiley Online Library
Human skin is a preferred vaccination site as it harbors multiple dendritic cell (DC) subsets,
which display distinct C‐type lectin receptors (CLR) that recognize pathogens. Antigens can …

[HTML][HTML] Mouse DC-SIGN/CD209a as target for antigen delivery and adaptive immunity

STT Schetters, LJW Kruijssen… - Frontiers in …, 2018 - frontiersin.org
The efficacy of vaccination studies aimed at targeting antigens to human DC-SIGN (hDC-
SIGN) have been notoriously difficult to study in vivo, as eight dendritic cell-specific …

[HTML][HTML] Systematic dual targeting of dendritic cell C-type lectin receptor DC-SIGN and TLR7 using a trifunctional mannosylated antigen

RJE Li, TP Hogervorst, S Achilli, SC Bruijns… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DCs) are important initiators of adaptive immunity, and they possess a
multitude of Pattern Recognition Receptors (PRR) to generate an adequate T cell mediated …

Targeted PLGA nano-but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

LJ Cruz, PJ Tacken, R Fokkink, B Joosten… - Journal of Controlled …, 2010 - Elsevier
Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine
components to dendritic cells (DCs), which are professional antigen presenting cells …

[HTML][HTML] Glyco-dendrimers as intradermal anti-tumor vaccine targeting multiple skin DC subsets

S Duinkerken, SK Horrevorts, H Kalay, M Ambrosini… - Theranostics, 2019 - ncbi.nlm.nih.gov
The human skin is an attractive anti-tumor vaccination site due to the vast network of
dendritic cell (DC) subsets that carry antigens to the draining lymph nodes and stimulate …

Boosting antibody responses by targeting antigens to dendritic cells

I Caminschi, K Shortman - Trends in immunology, 2012 - cell.com
Delivering antigens directly to dendritic cells (DCs) in situ, by injecting antigens coupled to
antibodies specific for DC surface molecules, is a promising strategy for enhancing vaccine …

Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes

AJ Affandi, J Grabowska, K Olesek… - Proceedings of the …, 2020 - National Acad Sciences
Priming of CD8+ T cells by dendritic cells (DCs) is crucial for the generation of effective
antitumor immune responses. Here, we describe a liposomal vaccine carrier that delivers …