[HTML][HTML] Focal adhesion kinase: from biological functions to therapeutic strategies

X Tan, Y Yan, B Song, S Zhu, Q Mei, K Wu - Experimental Hematology & …, 2023 - Springer
Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

[HTML][HTML] Targeting focal adhesion kinase in cancer cells and the tumor microenvironment

JM Murphy, YAR Rodriguez, K Jeong… - … & molecular medicine, 2020 - nature.com
Focal adhesion kinase (FAK) is an integrin-associated protein tyrosine kinase that is
frequently overexpressed in advanced human cancers. Recent studies have demonstrated …

Emerging roles of focal adhesion kinase in cancer

YL Tai, LC Chen, TL Shen - BioMed research international, 2015 - Wiley Online Library
Focal adhesion kinase (FAK) is a cytoplasmic nonreceptor tyrosine kinase that enables
activation by growth factor receptors or integrins in various types of human cancers. The …

Focal adhesion kinase as a potential target in oncology

GW McLean, E Avizienyte… - Expert opinion on …, 2003 - Taylor & Francis
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a pivotal role in
signal transduction at integrin-linked cellular adhesions, which mediate cell contact with the …

[HTML][HTML] FAK in cancer: from mechanisms to therapeutic strategies

HH Chuang, YY Zhen, YC Tsai, CH Chuang… - International journal of …, 2022 - mdpi.com
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

FAK in cancer: mechanistic findings and clinical applications

FJ Sulzmaier, C Jean, DD Schlaepfer - Nature reviews cancer, 2014 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

[HTML][HTML] Targeting focal adhesion kinase using inhibitors of protein-protein interactions

A Mousson, E Sick, P Carl, D Dujardin, J De Mey… - Cancers, 2018 - mdpi.com
Focal adhesion kinase (FAK) is a cytoplasmic non-receptor protein tyrosine kinase that is
overexpressed and activated in many human cancers. FAK transmits signals to a wide range …

Focal adhesion kinase inhibitors in the treatment of solid tumors: Preclinical and clinical evidence

PA Quispe, MJ Lavecchia, IE León - Drug Discovery Today, 2022 - Elsevier
Abstract Focal Adhesion Kinase (FAK) is a 125-kDa cytoplasmic protein kinase that is
implicated in several cellular functions. This protein is an attractive molecular target for …

Focal adhesion kinase as a cancer therapy target

VM Golubovskaya - Anti-Cancer Agents in Medicinal …, 2010 - ingentaconnect.com
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of at
focal adhesions. The 125 kDa FAK protein is encoded by the FAK gene located on human …

Signal transduction by focal adhesion kinase in cancer

J Zhao, JL Guan - Cancer and Metastasis Reviews, 2009 - Springer
Cellular interactions with extracellular matrix play essential roles in tumor initiation,
progression and metastasis. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase …