During carcinogenesis, advanced tumors are surrounded by both stromal and immune cells,
which support tumor development. In addition, inflammation and angiogenesis are …

Inflammatory mediators in tumor microenvironment influence cancer occurrence, growth and
metastasis through complex signaling networks. Excessive inflammation is closely …

Many pathological processes including wound healing, chronic inflammation and cancer
require angiogenesis, ie, the formation of new vasculature in the lesions. Accumulating …

Angiogenesis, the formation of new blood vessels, as well as inflammation with massive
infiltration of leukocytes are hallmarks of various tumor entities. Various epidemiological …

Since Virchow first proposed in 1863 that tumors could originate from sites of chronic
inflammation, it has been well established that chronic inflammation both contributes to …

The role of angiogenesis in the growth of organs and tumors is widely recognized. Vascular–
organ interaction is a key mechanism and a concept that enables an understanding of all …

The link with chronic inflammation and cancer has been recognized for certain cancers for
several decades. However, only recently has the biology of chronic inflammation begun to …

Simple Summary Tumor growth in solid cancers requires adequate nutrient and oxygen
supply, provided by blood vessels created by angiogenesis. Numerous studies have …

Endothelial-immune cell cross-talk goes well beyond leukocyte and lymphocyte trafficking,
since immune cells are able to intimately regulate vessel formation and function. Here we …

It is widely accepted that the tumor microenvironment (TUMIC) plays a major role in cancer
and is indispensable for tumor progression. The TUMIC involves many “players” going well …