Streptococcus pneumoniae cause considerable morbidity and mortality, with persistent
neurological sequelae, particularly in young children and the elderly. It is widely assumed …

Olfactory ensheathing cells (OECs) are a special glia that ensheath olfactory receptor axons
that enter the brain via olfactory phila, thus, providing a potential route for access of …

Using two different animal models of Streptococcus pneumoniae infection, we have
demonstrated that this organism is able to spread to the central nervous system and cause …

Opportunistic bacterial infections of the nasal cavity could potentially lead to infection of the
brain if the olfactory or trigeminal nerves are colonised. The olfactory nerve may be a more …

The primary olfactory nerves provide uninterrupted conduits for neurotropic pathogens to
access the brain from the nasal cavity, yet infection via this route is uncommon. It is …

Effective laboratory animal models of bacterial meningitis are needed to unravel the
pathophysiology of this disease. Previous models have failed to simulate human meningitis …

The correlation between carbohydrate availability, pneumococcal biofilm formation,
nasopharyngeal colonization, and invasion of the host has been investigated. Of a series of …

Abstract Sensorineural deafness occurs in 20%–30% of children after Streptococcus
pneumoniae meningitis. An infant rat model of S. pneumoniae meningitis was developed to …

The toxicity of pneumococci and endotoxin in primary cultures of rat neurons, astrocytes, and
microglia and in a human astrocyte and two human glial cell lines was determined. Heat …

The development of hearing loss and concomitant cerebrospinal fluid (CSF) cytochemical
changes in a model of pneumococcal meningitis were examined. Rabbits were injected …