In both the MHC class II and class I pathways of antigen presentation, accessory molecules
influence formation of MHC–peptide complexes. In the MHC class II pathway, DM functions …

Cytotoxic and helper T cells respond to peptides derived from endogenous and exogenous
sources that bind to major histocompatibility complex (MHC) class I and class II molecules …

Peptide assembly with class I molecules is orchestrated by multiple chaperones including
tapasin, which bridges class I molecules with the TAP and is critical for efficient Ag …

Antigen presentation is a cellular process that involves a number of steps, beginning with
the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides …

In B cells, the non‐classical human leukocyte antigens HLA‐DO (DO) and HLA‐DM (DM)
are residents of lysosome‐like organelles where they form tight complexes. DM catalyzes …

In human cells the association of MHC class I molecules with TAP is thought to be mediated
by a third protein termed tapasin. We now show that tapasin is present in murine TAP-class I …

Class I histocompatibility molecules, consisting of a heavy chain, β2‐microglobulin and
peptide, are assembled in the endoplasmic reticulum (ER) with the assistance of several …

Background: Class II molecules of the major histocompatibility complex become loaded with
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …

We recently discovered that TAPBPR promotes reglucosylation of the N-linked glycan on
MHC class I molecules, a modification that restores their recognition by calreticulin and …

Tapasin influences the quantity and quality of MHC/peptide complexes at the cell surface;
however, little is understood about the structural features that underlie its effects. Because …