Pain is defined by the International Association for the Study of Pain as “an unpleasant
sensory and emotional experience associated with actual or potential tissue damage, or …

It is well known to the regular readers of this Journal that chronic pain is a major health care
problem as defined by the World Health Organization. A recent literature review showed a 1 …

Background: Assessing analgesic drugs developed over preceding 50 years demonstrated
that very intensive efforts directed at diverse molecular pain targets produced thousands of …

In the general population, the sensation of pain is generally perceived in a negative
connotation because of its association with physical damage to the body and its unpleasant …

Pain is a symptom of many clinical disorders, afflicts a large proportion of the population and
is largely treated by pharmacological means. However, the two main classes of drugs used …

The traditional stimulus-response model of physiologic pain is conceptually appealing and
has laid the foundation for a more comprehensive understanding of nociceptive pathways …

Pain can be defined as an unpleasant sensory and emotional experience of actual or
potential tissue damage or an experience expressed in such terms. Both excitatory and …

Pain serves a vital biological defensive function, often associated with other psychological
and central disturbances. It is a physiological condition, which is detected by refined …

The pharmacological treatment of chronic pain is generally hampered by a limited clinical
outcome. Hence, there is a strong need for new therapeutic concepts considering the …

Acute pain can be successfully controlled by a variety of pharmacological agents, yet
clinically significant chronic pain, resulting from inflammation or nerve injury, is …